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The Actions of Glucagon at Its Receptor: Regulation of Adenylate Cyclase

  • Chapter
Glucagon I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 1))

Abstract

The “second messenger” concept of hormone action, first proposed nearly 20 years ago, states that hormones generally act by changing the levels of chemical signals produced by effector processes localized at the target cell plasma membrane (Sutherland 1972). These chemical signals govern in turn the activity of key intracellular enzymes that regulate, through a complex series of reactions, numerous metabolic processes in the cell. The concept of second messengers arose from the discovery that cyclic AMP mediates the actions of catecholamines and glucagon on glycogen metabolism in liver; numerous studies subsequently showed that cyclic AMP mediates the actions of a large number of hormones and neurotransmitters and that the latter agents act by either stimulating or inhibiting the nucleotide’s production (Rodbell 1978). Although the correlations between cyclic AMP production and hormone action are generally good, it must be emphasized that proof is lacking that regulation of cyclic AMP levels is the single action responsible for all effects of hormones or neurotransmitters. As a model process, however, hormonal regulation of cyclic AMP production has proven to be ideal since it can be observed with isolated preparations of membranes from a variety of sources.

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  1. M. Rodbell
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Editors and Affiliations

  1. University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Mèdecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefèbvre M.D (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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Rodbell, M. (1983). The Actions of Glucagon at Its Receptor: Regulation of Adenylate Cyclase. In: Lefèbvre, P.J. (eds) Glucagon I. Handbook of Experimental Pharmacology, vol 66 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68866-9_13

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  • DOI: https://doi.org/10.1007/978-3-642-68866-9_13

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