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Metabolic Interconversion of Enzymes 1980 pp 28–43Cite as

Classification of Protein Phosphatases Involved in Cellular Regulation

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Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The discovery that glycogen phosphorylase was controlled by a phosphorylation-dephosphorylation mechanism [1] was the first example of enzyme regulation by reversible covalent modification, and phosphorylase kinase [2] and glycogen synthase [3] were the second and third enzymes in which this phenomenon was identified. However, enzyme regulation by phosphorylation-dephosphorylation is not confined to glycogen metabolism and over 20 enzymes are now known to be controlled in this manner [4]. An important generality that seems to be emerging is that enzymes in biodegradative pathways are activated by phosphorylation whereas enzymes in biosynthetic pathways are inactivated by phosphorylation [5, 6] (Table 1). Two implications of this finding are that different enzymes may be regulated by the same protein kinases and protein phosphatases, or that different protein kinases and protein phosphatases may respond to the same effector molecules. These ideas are already established in the case of cyclic AMP-dependent protein kinase (cAMP-PrK) and Ca2+-calmodulin dependent protein kinases.

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Author information

Author notes

  1. J. Goris

    Present address: Faculteit der Geneeskunde, Afdeling Biochimie, Katholieke Universitet, Leuven, Campus Gasthuisberg, 3000, Leuven, Belgium

  2. S. T. Strada

    Present address: Department of Pharmacology, University of Texas, Health Science Center, Houston, Texas, 77025, USA

Authors and Affiliations

  1. Department of Biochemistry, University of Dundee, Dundee, DD1 4HN, Scotland

    P. Cohen, J. G. Foulkes, B. A. Hemmings, T. S. Ingebritsen & A. A. Stewart

Authors
  1. P. Cohen
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  2. J. G. Foulkes
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  3. J. Goris
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  4. B. A. Hemmings
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  5. T. S. Ingebritsen
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  6. A. A. Stewart
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  7. S. T. Strada
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Editor information

Editors and Affiliations

  1. Biochemisches Institut, Albert-Ludwigs-Universität, Hermann-Herder-Str. 7, 7800, Freiburg, Germany

    Helmut Holzer

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© 1981 Springer-Verlag, Berlin Heidelberg

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Cohen, P. et al. (1981). Classification of Protein Phosphatases Involved in Cellular Regulation. In: Holzer, H. (eds) Metabolic Interconversion of Enzymes 1980. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68211-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-68211-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68213-1

  • Online ISBN: 978-3-642-68211-7

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