Abstract
A number of studies have led to the conclusion that each differentiated cell nucleus includes not only all of the genes ever utilized in the organism but also transcripts of most of these genes. A direct implication is that both the quantitative and qualitative structure of cytoplasmic messenger RNA populations are controlled posttranscriptionally. The control process would function by determining the fraction from 0 to 100% of the potential mRNA precursors from each gene that survive and that are processed and transferred to the cytoplasm (Davidson et al. 1977). Only for those few mRNAs which are represented at very high concentration in the cell, such as the globin mRNA in reticulocytes, has evidence been presented that regulation may occur at the transcription level (Tobin et al. 1978).
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References
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© 1981 Springer-Verlag Berlin Heidelberg
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Torelli, U. et al. (1981). Different Frequency Classes of Sequences in Heterogeneous Nuclear RNA of Normal Promyelocytes and Lymphoblasts and of Leukemic Blast Cells of Circulating Blood and of the HL60 Line. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_95
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DOI: https://doi.org/10.1007/978-3-642-67984-1_95
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