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Chemistry of Neolignans with Potential Biological Activity

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New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

The two classes of naturally occurring dimeric lignoids (58) comprise the lignans (34) and the neolignans (29), generated, respectively, by the oxidative coupling of cinnamic acids (Formula 1.1) and/or cinnamyl alcohols (Formula 1.2) and of propenylphenols (Formula 1.3) and/ or allylphenols (Formula 1.4). Examples of lignans are podophyllotoxin (Formulas 1.5, ex 1.1 and 1.2) (33), pinoresinol (Formulas 1.7, ex 1.2 and 1.2) (56), steganacin (Formulas 1,9, ex 1.1 and 1.2) (39) and hordatine (Formulas 1.11, ex 1.1 and 1.1) (51); examples of neolignans are otobain (Formulas 1.6, ex 1.3 and 1.3) (27), nor-dihydroguaiaretic acid (Formulas 1.8, ex 1.3 and 1.3) (55), schizandrin (Formulas 1.10, ex 1.3 and 1.3) (38) and piperenone (Formulas 1.12, ex 1.3 and 1.4) (41).

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  1. O. R. Gottlieb
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  1. Institut für Pharmazeutische Arzneimittellehre, Universität München, Karlstraße 29, 8000, München 2, Germany

    H. Wagner  & P. Wolff  & 

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Gottlieb, O.R. (1977). Chemistry of Neolignans with Potential Biological Activity. In: Wagner, H., Wolff, P. (eds) New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66682-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-66682-7_10

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