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Prions Prions Prions

  • Book
  • © 1996

Overview

Editors:
  1. Stanley B. Prusiner

    1. Department of Neurology, University of California, San Francisco, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 207)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-vii
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  2. Human Prion Diseases and Neurodegeneration

    • S. B. Prusiner
    Pages 1-17

  3. Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease: A Tale of Two Diseases with the Same Genetic Mutation

    • P. Gambetti
    Pages 19-25

  4. Human Prion Disease and Human Prion Protein Disease

    • T. Kitamoto, J. Tateishi
    Pages 27-34

  5. Prion Strains

    • G. A. Carlson
    Pages 35-47

  6. Structures of Prion Proteins and Conformational Models for Prion Diseases

    • Z. Huang, S. B. Prusiner, F. E. Cohen
    Pages 49-67

  7. The Folding Intermediate Concept of Prion Protein Formation and Conformational Links to Infectivity

    • J. Safar
    Pages 69-76

  8. Cell Biology of the Prion Protein

    • D. A. Harris, A. Gorodinsky, S. Lehmann, K. Moulder, S. L. Shyng
    Pages 77-93

  9. Transgenetics and Gene Targeting in Studies of Prion Diseases

    • M. R. D. Scott, G. C. Telling, S. B. Prusiner
    Pages 95-123

  10. Transgenetics and Neuropathology of Prion Diseases

    • S. J. DeArmond, S. B. Prusiner
    Pages 125-146

  11. Evidence for Two Prions in Yeast: [URE3] and [PSI]

    • R. B. Wickner, D. C. Masison
    Pages 147-160

  12. Back Matter

    Pages 161-167
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Keywords

About this book

A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature.
Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.

Reviews

"...a compilation of information that will be a reference for years to come for the specialised reader." British Jnl of Biomedical Science

Editors and Affiliations

  • Department of Neurology, University of California, San Francisco, USA

    Stanley B. Prusiner

Bibliographic Information

  • Book Title: Prions Prions Prions

  • Editors: Stanley B. Prusiner

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-60983-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1996

  • Softcover ISBN: 978-3-642-64640-9Published: 21 September 2011

  • eBook ISBN: 978-3-642-60983-1Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VII, 163

  • Topics: Virology, Neurology

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