Abstract
Organophosphorous esters (OP) are covalent inhibitors of serine esterases. Those OPs which inhibit acetylcholinesterases and are thus acutely toxic have been used worldwide as insecticides. Different physicochemical properties of the tri-aryl phosphates have lead to their widespread use as plasticizers and flame-retardants. Certain OPs, for instance some saligenin cyclic phosphates which are metabolites of tri-aryl phosphates, have relatively little acute anti-cholinesterase directed toxicity, but cause a paralytic neuropathy which is manifest 1–3 weeks after exposure. Two major epidemics of human OP-induced neuropathy have occurred in the past 60 years.
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© 1997 Springer-Verlag Berlin Heidelberg
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Glynn, P. (1997). Neuropathy Target Esterase (NTE): Molecular Characterisation and Cellular Localisation. In: Seiler, J.P., Vilanova, E. (eds) Applied Toxicology: Approaches Through Basic Science. Archives of Toxicology, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60682-3_30
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DOI: https://doi.org/10.1007/978-3-642-60682-3_30
Publisher Name: Springer, Berlin, Heidelberg
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