Abstract
Cancer is a disease resulting from alterations of cellular genes which cause phenotypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and there is no obvious family history suggesting an inherited disease. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual. Thus, the critical question which arises is “how do these genetic changes occur in somatic cells?”.
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References
Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66(6): 1191–1308
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© 1997 Springer-Verlag Berlin Heidelberg
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Kastan, M.B. (1997). Genetic Instability and Tumorigenesis: Introduction. In: Kastan, M.B. (eds) Genetic Instability and Tumorigenesis. Current Topics in Microbiology and Immunology, vol 221. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60505-5_1
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DOI: https://doi.org/10.1007/978-3-642-60505-5_1
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