Abstract
A prominent feature of the mucosal immune system is formed by IgA secreting cells located in the lamina propria, immediately beneath the epithelium. In the intestine of the mouse at least 15 million cells secrete IgA into the surrounding connective tissue [1]. Subsequently, secretory IgA is transported across the single layer of epithelial cells and pumped into the gut lumen. Here, IgA can bind to food antigens and to the numerous microorganisms (in humans about 1011 bacteria per gram colon contents!). This interaction may help to prevent invasion and infection of the body with microbes, e.g. by preventing binding to the mucus layer and the epithelial cells (‘immune exclusion’).
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References
Van der Heijden PJ, Stok W, and Bianchi ATJ. (1987). Contribution of immunoglobulin-secreting cells in the murine small intestine to the ‘background’ immunoglobulin production. Immunology 62: 551 – 555.
Mattioli C, and Tomasi T. (1973). The life span of IgA plasma cells from the mouse intestine. J Exp Med 138: 452 – 460.
Kroese FGM, Cebra JJ, Van der Cammen MJF, Kantor AB, and Bos NA. (1995). Contribution of B-l cells to intestinal IgA production in the mouse. Methods 8: 37 – 43.
Kroese FGM, Kantor AB, and Herzenberg LA. (1994). The role of B-l cells (Ly-1 B cells) in mucosal immune responses. In: Ogra PL, Lamm ME, McGhee JR, Mestecky J, Strober W, Bienenstock J (Eds) Handbook of Mucosal Immunology. Academic Press, Inc. San Diego, pp 217 – 224.
Lebman DA, Nomura DY, Coffman RL, and Lee FL. (1990). Molecular characterization of germline immunoglobulin A transcript produced during transforming growth factor type (3- induced isotype switching. Proc Natl Acad Sci USA 87: 3962 – 3966.
De Waard R, Dammers PM, Tung JW, Kantor AB, Wilshire JA, Bos NA, Herzenberg LA, and Kroese FGM. (1998). Presence of germline and full-length IgA mRNA transcripts among peritoneal B-l cells. Dev Immunol 6: 81 – 87.
Vogel LA, and Metzger DW. (1995). Approaches for the study of T-cell influences on Bl-cell function. Methods 8: 61 – 69.
Taki S, Schmitt M, Tarlington D, Forster I, and Rajewsky K. (1992). T cell-dependent antibody production by Ly-1 B cells. Ann N Y Acad Sci 651: 328 – 335.
Wetzel GD. (1990). Interleukin 5 regulation of peritoneal B-cell proliferation and antibody secretion. Scand. J. Immunol. 31: 91 – 101
Hitoshi Y, Yamaguchi N, Tominaga A, and Takatsu K. (1992). Coexpression of CD5 and IL- 5 receptor on peritoneal B cells. Ann N Y Acad Sci 651: 261 – 263
Takatsu K, Kariyone A, Kouro T, Kikuchi Y, Hitoshi Y, and Takaki S. (1995). Interleukin-5 receptor and CD5-positive B cells. Methods 8: 45 – 59.
Bao S, Beagley KW, Murray AM, Caristo V, Matthaei KI, Young G, and Husband AJ. (1998). Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent. Immunology 94: 181 – 188.
Baumgarth N, Egerton M, and Kelso A. (1997). Activated T cells from draining lymph nodes and effector site differ in their responses to TCR stimulation. J Immunol 159: 1182 – 1191.
Hardy RR, and Hayakawa K. (1992). Developmental origins, specificities and immunoglobulin gene biases of murine Ly-1 B cells. Int Rev Immunol 8: 189 – 207.
Bos NA, Bun JCAM, Popma SH, Cebra ER, Deenen GJ, Cammen MJFvd, Kroese FGM, and Cebra JJ. (1996). Monoclonal Immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and reactive with commensal bacteria. Inf Immun 64: 616 – 623.
Quan CP, Berneman A, Pires R, Avrameas S, and Bouvet JP. (1997). Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans. Inf Immun 65: 3997 – 4004.
Marcotte H, and Lavoie MC. (1996). No apparent influence of immuno-globulins on indigenous oral and intestinal microbiota of mice. Inf Immun 64: 4694 – 4699.
Kroese FGM, De Waard R, and Bos NA. (1996). B1 cells and their reactivity with the murine intestinal microflora. Sem Immunol 8: 11 – 18
Van der Waaij LA, Limburg PC, Mesander G, and Van der Waaij D. (1996). In vivo IgA coating of anaerobic bacteria in human faeces. Gut 38: 348 – 354.
Bos NA, Rijsemus AN, Van de Werf M, Schut F, and Welling GW. 1997. Usage of 16S rRNA in situ hybridisation to study bacterial population dynamics in host-flora interactions. In: Hashimoto K, Sakakibara B, Tazume S, Shimizu K (Ed) Germfree life and its ramifications. XIIISG Publishing Committee, Shiozawa, pp 231 – 235.
Potter M, and Wiener F. (1992). Plasmacytomagenesis in mice: a model of neoplastic development dependent upon chromosomal translocations. Carcinogenesis 13: 1681 – 1697.
Michetti P, Mahan MJ, Slauch JM, Mekalanos JJ, and Neutra MR. (1992). Monoclonal secretory immunoglobulin A protects mice against oral challlenge with the invasive pathogen Salmonella typhimurium. Inf Immun 60: 1786 – 1792.
Apter FM, Lenger WI, Finkelstein RA, Mekalanos JJ, and Neutra MR. (1993). Monoclonal immunoglobulin a antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro. Inf Immun 61: 5271 – 5278.
Michetti P, Porta N, Mahan MJ, Slauch JM, Mekalanos JJ, Blum AL, Kraehenbuhl J, and Neutra MR. (1994). Monoclonal immunoglobulin A prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium. Gastroenterology 107: 915 – 923.
Shroff KE, Meslin K, and Cebra JJ. (1995). Commensal enteric bacteria engender a self- limiting humoral mucosal immune response while permanently colonizing the gut. Inf Immun 63: 3904 – 3913.
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© 1999 Springer-Verlag Berlin Heidelberg
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Kroese, F.G.M., Bos, N.A. (1999). Peritoneal B-1 Cells Switch in vivo to IgA and these IgA Antibodies can bind to Bacteria of the Normal Intestinal Microflora. In: Melchers, F., Potter, M. (eds) Mechanisms of B Cell Neoplasia 1998. Current Topics in Microbiology and Immunology, vol 246. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60162-0_42
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DOI: https://doi.org/10.1007/978-3-642-60162-0_42
Publisher Name: Springer, Berlin, Heidelberg
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