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Vascular Growth Factors and Angiogenesis pp 85–96Cite as

Vascular Endothelial Growth Factor Receptor-3

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 237))

Abstract

Cell-cell communication during vascular development and tumour angiogenesis seems to involve at least five endothelial cell-specific tyrosine kinase receptors belonging to two distinct subclasses: two receptors of the Tie family, and three vascular endothelial cell growth factor receptors, VEGFR-1, -2 and -3, originally named Fltl (Fms-like tyrosine kinase), KDR/Flk-1 (Kinase insert-domain containing receptor or fetal-liver kinase-1) and Flt4, respectively. VEGFRs are subclass-III receptor tyrosine kinases, homologous to the platelet-derived growth factor (PDGF)-receptor family, having seven immunoglobulin homology domains in the extracellular domain, and a tyrosine kinase intracellular domain split by a kinase insert sequence (for recent reviews, see Klagsbrun and D’Amore 1996; Folkman and D’Amore 1996; Mustonen and Alitalo 1995; Korpelainen and Alitalo, 1998, Claesson-WELSH, this book).

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Author information

Authors and Affiliations

  1. Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, P.O.B. 21 (Haartmaninkatu 3), FIN-00014, Helsinki, Finland

    J. Taipale, T. Makinen, E. Arighi, E. Kukk, M. Karkkainen & K. Alitalo

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  1. J. Taipale
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  2. T. Makinen
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  3. E. Arighi
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  4. E. Kukk
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  5. M. Karkkainen
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  6. K. Alitalo
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Editor information

Editors and Affiliations

  1. Department of Medical Biochemistry and Microbiology Biomedical Center, University of Uppsala, Box 575, Uppsala, S-75123, Sweden

    Lena Claesson-Welsh

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© 1999 Springer-Verlag Berlin Heidelberg

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Taipale, J., Makinen, T., Arighi, E., Kukk, E., Karkkainen, M., Alitalo, K. (1999). Vascular Endothelial Growth Factor Receptor-3. In: Claesson-Welsh, L. (eds) Vascular Growth Factors and Angiogenesis. Current Topics in Microbiology and Immunology, vol 237. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59953-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-59953-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64195-4

  • Online ISBN: 978-3-642-59953-8

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