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Antisense Research and Application pp 243–262Cite as

Immune Stimulation by Oligonucleotides

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 131))

Abstract

As has been pointed out previously ([Stein and Cheng 1993]), DNA is a polyanion. Like other polyanions, DNA can have a broad range of biologic effects. Native or modified DNA backbones can cause immune activation which is concentration-and length-dependent and sequence-independent. However, the different backbones currently under development for antisense applications differ greatly in the degree to which they induce immune effects. As might be expected, neutral backbones have minimal, if any, immune effects (A.M. Krieg, unpublished observation). Among the charged backbones that have been carefully investigated, the greatest magnitude of nonspecific effects are seen with phosphorothioate oligodeoxynucleotides (PS-ODNs) ([Stein and Cheng 1993]).

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  1. A. M. Krieg
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  1. ISIS Pharmaceuticals, Inc., Carlsbad Research Center, 2292 Faraday Avenue, Carlsbad, CA, 92008, USA

    Stanley T. Crooke M.D., Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Krieg, A.M. (1998). Immune Stimulation by Oligonucleotides. In: Crooke, S.T. (eds) Antisense Research and Application. Handbook of Experimental Pharmacology, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58785-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-58785-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63730-8

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