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Successful Administration of the NO Synthase Inhibitor 546C88 as a Delayed Continuous Infusion in a Baboon Model of Septic Shock

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Shock, Sepsis, and Organ Failure

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Abstract

Nitric oxide (NO) as both a vasodilator and under certain circumstances a cyto-toxic molecule is suggested as one of the critical mediators of severe sepsis and septic shock. Whether NO is really a central molecule in sepsis and whether inhibition/scavenging has more beneficial or detrimental effects are, however, controversial questions with conflicting data. Many studies demonstrate either one or both effects; these have been thoroughly reviewed recently [1].

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Authors
  1. Günther Schlag
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  2. Heinz Redl
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  3. H. Gasser
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  4. Z. Khakpour
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  5. J. Davies
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Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, 1200, Wien, Austria

    Günther Schlag  & Heinz Redl  & 

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© 1999 Springer-Verlag Berlin Heidelberg

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Schlag, G., Redl, H., Gasser, H., Khakpour, Z., Davies, J. (1999). Successful Administration of the NO Synthase Inhibitor 546C88 as a Delayed Continuous Infusion in a Baboon Model of Septic Shock. In: Schlag, G., Redl, H. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58630-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-58630-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63672-1

  • Online ISBN: 978-3-642-58630-9

  • eBook Packages: Springer Book Archive

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