Abstract
Differentiation models for hematopoietic stem cells are to experimental hematologists what metabolic pathway charts are to biochemists. It has been extremely useful to consider the results of gene targeting and other experiments within the context of diagrams predicting key steps in B and T lymphopoiesis. Comparable schemes for human cells allow assignment of malignant cells to particular differentiation stages and interpretation of immunodeficiencies. Practical advances in multi-parameter flow cytometry and commercially available monoclonal antibodies further account for the popularity of differentiation schemes depicted on the walls of most laboratories. However, there is reason to believe that these models are not accurate or sufficiently complete in all respects. We will briefly recount how our recent studies forced re-evaluation of some widely accepted milestones for murine B lineage differentiation.
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Kincade, P.W. et al. (2000). Re-evaluation of B Lymphocyte Lineage Differentiation Schemes. In: Melchers, F. (eds) Lymphoid Organogenesis. Current Topics in Microbiology and Immunology, vol 251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57276-0_9
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DOI: https://doi.org/10.1007/978-3-642-57276-0_9
Publisher Name: Springer, Berlin, Heidelberg
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