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Inhibitoren zyklischer Nukleotid-Phosphodiesterasen reduzieren die Mikrozirkulationsstörung und den Gewebeschaden in hepatischer Ischämie-Reperfusion

Cyclic nucleotide phosphodiesterase inhibitors ameliorate microcirculation failure after warm ischemia in rat livers

  • Conference paper
Chirurgisches Forum 2001 für experimentelle und klinische Forschung

Part of the book series: Deutsche Gesellschaft für Chirurgie ((FORUMBAND,volume 30))

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Abstract

To determine the effect of phosphodiesterase inhibitors, milrinone and zaprinast on a hepatic warm ischemia-reperfusion injury, changes in hepatic microcirculation and liver injury were examined in a partial hepatic warm ischemia-reperfusion model in rats. In milrinone- and zaprinast-pretreated rats, leukocyte-endothelial interaction was suppressed and hepatic microcirculation was ameliorated after reperfusion. ALT blood level was significantly suppressed by these treatments. Milrinone augmented cAMP and zaprinast elevated cAMP and cGMP concentrations in the liver tissue. These data suggested that cyclic nucleotides may have some important function in this tolerance induction mechanism against ischemia-reperfusion injury.

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Authors and Affiliations

  1. Chirurgische Klinik, Germany

    Dr. med. M. Kume, Dr. med. M. Kume, R. Banafsche, Y. Yamamoto, Y. Yamaoka, W. Fiehn, M. M. Gebhard, C. Herfarth & E. Klar

Authors
  1. Dr. med. M. Kume
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  2. R. Banafsche
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  3. Y. Yamamoto
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  4. Y. Yamaoka
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  5. W. Fiehn
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  6. M. M. Gebhard
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  7. C. Herfarth
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  8. E. Klar
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Corresponding author

Correspondence to M. Kume .

Editor information

Editors and Affiliations

  1. Klinikum der Stadt Ludwigshafen, Bremserstraße 79, 67063, Ludwigshafen, Germany

    K. Schönleben (Präsident des 118. Kongresses der Deutschen Gesellschaft für Chirurgie, Direktor der Chirurgischen Klinik) (Präsident des 118. Kongresses der Deutschen Gesellschaft für Chirurgie, Direktor der Chirurgischen Klinik)

  2. II. Chirurgischer Lehrstuhl Universität zu Köln, Ostmerheimer Straße 200, 51109, Köln, Germany

    E. Neugebauer (Vorsitzender der Sektion Chirurgische Forschung, Leiter der Biochemischen und Experimentellen Abteilung) (Vorsitzender der Sektion Chirurgische Forschung, Leiter der Biochemischen und Experimentellen Abteilung)

  3. Luisenstraße 58/59, 10117, Berlin, Germany

    W. Hartel (Generalsekretär der Deutschen Gesellschaft für Chirurgie) (Generalsekretär der Deutschen Gesellschaft für Chirurgie)

  4. Universität des Saarlandes, 66421, Homburg/Saar, Germany

    M. D. Menger (Direktor der Abteilung für Klinisch-Experimentelle Chirurgie) (Direktor der Abteilung für Klinisch-Experimentelle Chirurgie)

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© 2001 Springer-Verlag Berlin Heidelberg

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Kume, M. et al. (2001). Inhibitoren zyklischer Nukleotid-Phosphodiesterasen reduzieren die Mikrozirkulationsstörung und den Gewebeschaden in hepatischer Ischämie-Reperfusion. In: Schönleben, K., Neugebauer, E., Hartel, W., Menger, M.D. (eds) Chirurgisches Forum 2001 für experimentelle und klinische Forschung. Deutsche Gesellschaft für Chirurgie, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56698-1_89

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  • DOI: https://doi.org/10.1007/978-3-642-56698-1_89

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41718-7

  • Online ISBN: 978-3-642-56698-1

  • eBook Packages: Springer Book Archive

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