Overview
- Detailed coverage of the most recent developments in targeted cancer therapy using small molecules
- Full discussion of preclinical studies, clinical trials, and treatment applications
- Written by acknowledged experts
- Includes supplementary material: sn.pub/extras
Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 201)
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About this book
Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.
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Keywords
Table of contents (25 chapters)
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Front Matter
Reviews
“The book is recommended for healthcare professionals, scientists, and students in medical and scientific fields. In 25 well-written chapters, experts in their fields of research describe in great detail 12 compounds currently in clinical use for the treatment of hematological malignancies, and 13 compounds applicable to specific mutation-containing malignancies or aimed at interfering with the microenvironment (such as angiogenesis). … This book provides important practical information on a wide variety of novel small molecule-based treatment approaches.” (George Somlo, Doody's Book Reviews, April, 2015)
Editors and Affiliations
Bibliographic Information
Book Title: Small Molecules in Oncology
Editors: Uwe M. Martens
Series Title: Recent Results in Cancer Research
DOI: https://doi.org/10.1007/978-3-642-54490-3
Publisher: Springer Berlin, Heidelberg
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2014
Hardcover ISBN: 978-3-642-54489-7Published: 12 May 2014
Softcover ISBN: 978-3-662-51925-7Published: 23 August 2016
eBook ISBN: 978-3-642-54490-3Published: 22 April 2014
Series ISSN: 0080-0015
Series E-ISSN: 2197-6767
Edition Number: 2
Number of Pages: XVI, 417
Number of Illustrations: 20 b/w illustrations, 26 illustrations in colour
Additional Information: The third edition of this book will be published in two volumes
Topics: Oncology, Hematology, Cancer Research