Abstract
As an intracellular parasite, Toxoplasma gondii evades direct attack by the humoral immune response. Host defense reactions which efficiently strike the pathogen within the parasitophorous vacuole are cell-mediated and result either in lysis of the host cell or in its activation to inhibit intracellular parasite growth. Several populations of immune cells are crucially involved in both effector pathways: natural killer cells, CD8+ T lymphocytes and CD4+ T cells of the helper 1 (Th1) subtype. Each of these cell types is able to produce interferon-γ(IFN-γ), the prerequisite mediator of protective immunity to T. gondii. IFN-γ triggers antiparasitic activity in macrophages and other cells. The relevance of immune-mediated host cell lysis for the control of acute or chronic infection still needs to be clarified.
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© 1996 Springer-Verlag Berlin Heidelberg
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Fischer, H.G., Reichmann, G., Hadding, U. (1996). Toxoplasma Proteins Recognized by Protective T Lymphocytes. In: Gross, U. (eds) Toxoplasma gondii. Current Topics in Microbiology and Immunology, vol 219. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51014-4_16
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DOI: https://doi.org/10.1007/978-3-642-51014-4_16
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