Abstract
During B cell development differentiation is accompanied by the selective activation of some genes and the repression of other genes. We wish to identify and characterize transcription factors responsible for the activation and repression of gene expression.
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References
Calame K (1985) Mechanisms that regulate immunoglobulin gene expression. In: Paul WE (ed) Annual review of immunology, vol. 3. Annual Reviews Inc., CA., p 159
Chodosh LA, Carthew RW, Sharp PA (1986) A single polypeptide possesses the binding and transcription activities of the Adenovirus major late transcription factor. Mol. Cell. Biol. 6: 4723–4733
Feo S, ar-Rushdi A, Heubner K, Finan J, Nowell P, Clarkson B, Croce C (1985) Suppression of the normal mouse c-myc oncogene in human lymphoma cells Nature (London) 313:493–495.
Kadesch T, Zervos P, Ruezinsky D (1986) Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity. Nucleic Acids Res. 14: 8209–8221
Kadonaga JT, Tjian R (1986) Affinity purification of sequence-specific DNA binding proteins. Proc. Natl. Acad. Sci. USA 83: 5889–5893
Kakkis E, Mercola M, Calame K (1987) Strong transcriptional activation of translocated c-myc genes occurs without a strong nearby enhancer or promoter. (manuscript submitted)
Kakkis E, Calame K (1987) A plasmacytoma-specific factor binds the c-myc promoter region. Proc. Natl. Acad. Sci. USA (in press)
Lenardo M, Pierce JW, Baltimore D (1987) Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236: 1573–1577
Peterson CL, Calame K (1987) Complex protein binding within the mouse immunoglobulin heavy chain enhancer. Mol. Cell. Biol. (in press)
Mercola M, Goverman J, Mirell C, Calame K (1985) Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors. Science 227: 266–270
Scholer HR, Gruss P (1985) Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J. 4: 3005–3013
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© 1988 Springer-Verlag Berlin · Heidelberg
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Peterson, C.L., Tsao, B., Kakkis, E., Calame, K.L. (1988). Transcription Factors in Terminally Differentiated B Cells. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_16
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DOI: https://doi.org/10.1007/978-3-642-50059-6_16
Publisher Name: Springer, Berlin, Heidelberg
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