Abstract
The HLADH is a dimer of molecular weight of about 80000. There are at least two distinctive types of subunits, E (ethanol active) and S (steroid active). These two types differ in the position of six amino acids, which seems to be the origin of the difference in their catalytic properties (Jörnvall 1970a,b). The replacement of only one of the six amino acids by another one results in the appearance of steroid activity (Eklund et al. 1976). It seems that the steroid activity is an intrinsic property of the enzyme rather than the activity toward ethanol because the latter is not a normal bodily constituent (Damgaard 1981).
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© 1986 Springer-Verlag Berlin Heidelberg
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Ohno, A., Ushida, S. (1986). Enzymatic Reductions. In: Mechanistic Models of Asymmetric Reductions. Lecture Notes in Bio-Organic Chemistry, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48868-9_4
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DOI: https://doi.org/10.1007/978-3-642-48868-9_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16440-1
Online ISBN: 978-3-642-48868-9
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