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Symposium Fibrinogen

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 88))

  • 33 Accesses

Zusammenfassung

Fibrinogen, the central protein of blood coagulation, is a giant molecule (Henschen 1981). It has a molecular weight of 340,000. The molecule is composed of three pains of non-identical peptide chains, Aα, Bβ and γ)2, and the structure can therefore be described as (Aα, Bβ and γ)2. During coagulation thrombin cleaves two of the peptide chain pairs, i.e., Aα and Bβ, within the amino-terminal parts of these chains. Hereby the fibrinopeptides A and B are released and fibrin, with the structure (α, β, γ)2, is formed. The peptide chains are held together by 29 disulfide bridges. Two of the chain pairs, Bβ and γ, have carbohydrate side chains attached. A schematic representation of the molecule is shown in Fig. 1.

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Authors and Affiliations

  1. Max-Planck-Inst. für Biochemie, Martinsried, Deutschland

    A. Henschen, M. Kehl, C. Southan & F. Lottspeich

  2. Inst. de Pathologie Cellulaire, Unité INSERM U143, Hopital de Bicêtre, Le Kremlin Bicêtre, France

    G. A. Marguerie & G. Courtois

  3. Dept. of Molecular Immunology Research Inst. of Scripps Clinic, La Jolla, USA

    E. F. Plow

  4. Dept. of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA

    H. L. Nossel, J. Owen & K. L. Kaplan

  5. I. Med. Klinik, Fakultät für klin. Medizin, Univ. Heidelberg, Städt. Klinikum, Mannheim, Deutschland

    D. L. Heene

  6. Mount Sinai Medical Center, Milwaukee, USA

    M. W. Mosesson

  7. Center for Thrombosis and Vascular Research, Dept. of Medical Research, Univ. of Leuven, Belgium

    M. Verstraete & D. Collen

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  1. A. Henschen
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  1. Kliniken der Landeshauptstadt Wiesbaden, D-6200, Wiesbaden, Deutschland

    Bernhard Schlegel

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Henschen, A. et al. (1982). Symposium Fibrinogen. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 88. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47093-6_28

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  • DOI: https://doi.org/10.1007/978-3-642-47093-6_28

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0332-0

  • Online ISBN: 978-3-642-47093-6

  • eBook Packages: Springer Book Archive

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