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Genes and Environment in Cancer

  • Conference proceedings
  • © 1998

Overview

Editors:
  1. Manfred Schwab

    1. Abteilung Zytogenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  2. Hartmut M. Rabes

    1. Pathologisches Institut, Universität München, München, Germany

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  3. Klaus Munk

    1. Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  4. Hans Peter Hofschneider

    1. Max-Planck-Institut für Biochemie, Martinsried, Germany

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 154)

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About this book

Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as "cancer".

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Table of contents (26 papers)

  1. Front Matter

    Pages I-XIV
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  3. Risk Assessment and DNA Lesions

    1. Front Matter

      Pages 37-37
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    2. Molecular Epidemiology of Environmental Carcinogenesis

      • F. P. Perera
      Pages 39-46

    3. Polymorphisms of N-Acetyltransferases, Glutathione S-Transferases, Microsomal Epoxide Hydrolase and Sulfotransferases: Influence on Cancer Susceptibility

      • J. G. Hengstler, M. Arand, M. E. Herrero, F. Oesch
      Pages 47-85

    4. Impact of Adduct Determination on the Assessment of Cancer Susceptibility

      • H. Bartsch, M. Rojas, K. Alexandrov, A. Risch
      Pages 86-96

    5. Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes

      • E. Dogliotti, P. Hainaut, T. Hernandez, M. D’Errico, D. M. Demarini
      Pages 97-124

  4. DNA Repair and Genetic Susceptibility

    1. Front Matter

      Pages 125-125
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    2. Relevance of DNA Repair to Carcinogenesis and Cancer Therapy

      • M. F. Rajewsky, J. Engelbergs, J. Thomale, T. Schweer
      Pages 127-146

    3. Molecular Basis of DNA Repair Mechanisms and Syndromes

      • G. Weeda, J. de Boer, I. Donker, J. de Wit, S. B. Winkler, G. T. J. van der Horst et al.
      Pages 147-155

    4. The Ataxia Telangiectasia Gene in Familial and Sporadic Cancer

      • M. A. R. Yuille, L. J. A. Coignet
      Pages 156-173

  5. Induced Chromosome Damage and Cancer

    1. Front Matter

      Pages 175-175
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    2. Cancer Predictive Value of Cytogenetic Markers Used in Occupational Health Surveillance Programs

      • L. Hagmar, S. Bonassi, U. Strömberg, Z. Mikoczy, C. Lando, I.-L. Hansteen et al.
      Pages 177-184

    3. Instability at Chromosomal Fragile Sites

      • T. W. Glover
      Pages 185-199

    4. The Role of Deletions at the FRA3B/FHIT Locus in Carcinogenesis

      • K. Huebner, T. Druck, Z. Siprashvili, C. M. Croce, A. Kovatich, P. A. McCue
      Pages 200-215

    5. Gene Amplification Mechanisms: The Role of Fragile Sites

      • M. Debatisse, A. Coquelle, F. Toledo, G. Buttin
      Pages 216-226

  6. Genetic Susceptibility and Environmental Exposure: “The RET Paradigm”

    1. Front Matter

      Pages 227-227
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    2. Mechanisms of Development of Multiple Endocrine Neoplasia Type 2 and Hirschsprung’s Disease by ret Mutations

      • M. Takahashi, N. Asai, T. Iwashita, H. Murakami, S. Ito
      Pages 229-236
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Editors and Affiliations

  • Abteilung Zytogenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

  • Pathologisches Institut, Universität München, München, Germany

    Hartmut M. Rabes

  • Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Klaus Munk

  • Max-Planck-Institut für Biochemie, Martinsried, Germany

    Hans Peter Hofschneider

Bibliographic Information

  • Book Title: Genes and Environment in Cancer

  • Editors: Manfred Schwab, Hartmut M. Rabes, Klaus Munk, Hans Peter Hofschneider

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-46870-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1998

  • Softcover ISBN: 978-3-642-46872-8Published: 01 March 2012

  • eBook ISBN: 978-3-642-46870-4Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XIV, 368

  • Number of Illustrations: 8 illustrations in colour

  • Topics: Oncology, Human Genetics

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