Abstract
Many halogenated alkenes undergo glutathione conjugation, followed by metabolism to the cysteine conjugates, which are nephrotoxic in vivo and in vitro in the rat (Lock EA (1988), CRC Crit. Rev. in Toxicol. 19, 1: 23–42). The toxicity is largely dependent on the activity of the renal C-S lyase.
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© 1998 Springer-Verlag Berlin Heidelberg
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McGoldrick, T.A., Lock, E.A., Hawksworth, G.M. (1998). Haloalkene Conjugate Toxicity: The Role of Human Renal Cysteine Conjugate C-S Lyase. In: Seiler, J.P., Autrup, J.L., Autrup, H. (eds) Diversification in Toxicology — Man and Environment. Archives of Toxicology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46856-8_43
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DOI: https://doi.org/10.1007/978-3-642-46856-8_43
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