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EXAFS Studies of Non-Blue Copper Proteins: Superoxide Dimutase, Dopamine-Monooxygenase and Monoamine Oxidase

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EXAFS and Near Edge Structure III

Part of the book series: Springer Proceedings in Physics ((SPPHY,volume 2))

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Abstract

The copper containing enzymes superoxide dismutase, dopamine monooxygenase and plasma amine oxidase while functionally diverse are often classified together as ‘non-blue’ or ‘type 2’ on the basis of the similarity of their optical and EPR spectroscopic properties to those of simple mononuclear complexes[1]. X-ray absorption spectroscopy offers a further method of examining the structural relationships within this class of copper proteins. In this paper we summarise the results of EXAFS studies, which provide evidence of structural homologies and have identified imidazole coordination in all three enzyme systems. In the case of native superoxide dismutase where a crystal structure is available to 2Å resolution[2, 3], comparison of EXAFS and crystal lographic coordinates using molecular graphics has provided extra insights into the local structure of the active site.

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of Manchester, Institute of Science and Technology, P.O. Box 88, Manchester, M60 10D, UK

    N. J. Blackburn

  2. Daresbury Laboratory, Warrington, Cheshire, WA4 4AD, UK

    S. S. Hasnain

  3. Department of Biophysics, University of Leeds, Leeds, LS2 9JT, UK

    P. F. Knowles

Authors
  1. N. J. Blackburn
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  2. S. S. Hasnain
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  3. P. F. Knowles
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Stanford University, Stanford, CA, 94305, USA

    Keith O. Hodgson , Britt Hedman  & James E. Penner-Hahn ,  & 

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© 1984 Springer-Verlag Berlin Heidelberg

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Blackburn, N.J., Hasnain, S.S., Knowles, P.F. (1984). EXAFS Studies of Non-Blue Copper Proteins: Superoxide Dimutase, Dopamine-Monooxygenase and Monoamine Oxidase. In: Hodgson, K.O., Hedman, B., Penner-Hahn, J.E. (eds) EXAFS and Near Edge Structure III. Springer Proceedings in Physics, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46522-2_33

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  • DOI: https://doi.org/10.1007/978-3-642-46522-2_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46524-6

  • Online ISBN: 978-3-642-46522-2

  • eBook Packages: Springer Book Archive

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