Abstract
The yield, the quality, and the nutritional safety of cereals can be seriously affected by the development, both in the field and during storage, of fungi that can produce several classes of mycotoxins, characterized by strong negative effects on the human and animal’s health. For the diseases control, modern strategies include the development of cereal resistant varieties obtained through classical or innovative breeding strategies, together with the application of biological agents and new “green” chemicals as pesticide. To this purpose, Medicinal and Aromatic Plants are a source of natural products useful in “environmental-friendly” organic and conventional farming. This chapter reviews the wide range of essential oils (EOs) and natural compounds that have been demonstrated to have fungicide and fungistatic effects against mycotoxigenic fungi of cereals. It also addresses their mechanisms of action against fungi and their impact on plants tissues both at cellular and molecular levels.
Keywords
- Powdery Mildew
- Aflatoxin Production
- Ergosterol Biosynthesis
- Trichothecene Production
- Mycotoxigenic Fungus
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Ahmed A, Randhawa MA, Yusuf MJ, Khalid N (2011) Effect of processing on pesticide residues in food crops—a review. J Agric Res 49(3):379–390
Ait-Ouazzou A, Cherrat L, Somolinos M, Lorán S, Rota C, Pagán R (2011a) The antimicrobial activity of hydrophobic essential oil constituents acting alone or in combined processes. Inn Food Sci Emerging Technol 12:320–329
Ait-Ouazzou A, Lorán S, Rota C, Bakalli M, Laglaoui A, Herrera A, Pagán R, Conchello P (2011b) Antimicrobial activity of Thymus algeriensis, Eucalyptus globulus and Rosmarinus officinalis essential oils from Morocco. J Sci Food Agric 91:2643–2651
Aldred D, Cairns-Fuller V, Magan N (2008) Environmental factors affect efficacy of some essential oils and resveratrol to control growth and ochratoxin A production by Penicillium verrucosum and Aspergillus westerdijkiae on wheat grain. J Stored Prod Res 44:341–346
Al-Reza SM, Rahman A, Ahmed Y, Kang SC (2010) Inhibition of plant pathogens in vitro and in vivo with essential oil and organic extracts of Cestrum nocturnum L. Pesticide Biochem Physiol 96:86–92
Atanda OO, Akpan I, Oluwafemi F (2007) The potential of some spice essential oils in the control of A. parasiticus CFR 223 and aflatoxin production. Food Control 18:601–607
Bajpai VK, Kang SC (2010) Antifungal activity of leaf essential oil and extracts of Metasequoia glyptostroboides Miki ex Hu. J Am Oil Chem Soc 87:327–336
Bankole SA (1997) Effect of essential oil from two Nigerian medicinal plants (Azadirachta indica and Morinda lucida) on growth and aflatoxin B1 production in maize grain by a toxigenic Aspergillus flavus. LAM 24:190–192
Bennett RN, Wallsgrove RM (1994) Secondary metabolites in plant defence mechanisms. New Phyt 127(4):617–633
Bi X, Guo N, Jin J, Liu, Feng H, Shi J, Xiang H, Wu X, Dong J, Hu H, Yan S, Yu C, Wang X, Deng X, Yu L (2009) The global gene expression profile of the model fungus Saccharomyces cerevisiae induced by thymol. J Appl Microbiol 108:712–722
Bluma R, Etcheverry M (2008) Application of essential oils in maize grain: impact on Aspergillus section Flavi growth parameters and aflatoxin accumulation. Food Microbiol 25:324–334
Burt S (2004) Essential oils: their antibacterial properties and potential applications in foods—a review. Int J Food Microbiol 94:223–253
Cardenas-Ortega NC, Zavala-Sanchez MA, Aguirre-Rivera JR, Perez-Gonzalez C, Perez-Gutierrez S (2005) Chemical composition and antifungal activity of essential oil of Chrysactinia mexicana gray. J Agric Food Chem 53:4347–4349
Carson CF, Hammer KA, Riley TV (2006) Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 19:50–62
Cawood ME, Pretorius JC, van der Westhuizen AJ, Pretorius ZA (2010) Disease development and PR-protein activity in wheat (Triticum aestivum) seedlings treated with plant extracts prior to leaf rust (Puccinia triticina) infection. Crop Prot 29:1311–1319
Chaimovitsh D, Abu-Abied M, Belausov E, Rubin B, Dudai N, Sadot E (2010) Microtubules are an intracellular target of the plant terpene citral. The Plant J 61:399–408
Chaimovitsh D, Rogovoy O, Altshuler O, Belausov E, Abu-Abied M, Rubin B, Sadot E, Dudai N (2011) The relative effect of citral on mitotic microtubules in wheat roots and BY2 cells. Plant Biol. doi:10.1111/j.1438-8677.2011.00511.x
Chulze SN (2010) Strategies to reduce mycotoxin levels in maize during storage: a review. Food Add Contam 27(5):651-657
Dan Y, Liu H-Y, Gao W-W, Chen S-L (2010) Activities of essential oils from Asarum hetrotropoides var. mandshuricum against five phytopathogens. Crop Prot 29:295–299
Dwivedi SK, Dubey NK (1993) Potential use of the essential oil of Trachyspermum ammi against seed-borne fungi of Guar (Cyamopsis tetragonoloba L. (Taub.)). Mycopathologia 121:101–104
Fandohan P, Gbenou JD, Gnonlonfin B, Hell K, Marasas WFO, Wingfield MJ (2004) Effect of essential oils on the growth of Fusarium verticillioides and fumonisin contamination in corn. J Agri Food Chem 52:6824–6829
Giannitti F, Diab SS, Pacin AM, Barrandeguy M, Larrere C, Ortega J, Uzal FA (2011) Equine leukoencephalomalacia (ELEM) due to fumonisins B1 and B2 in Argentina. Pesquisa Veterinária Brasileira 31(5):407–412
Gibriel YAY, Hamza AS, Gibriel AY, Mohsen SM (2011) In vivo effect of mint (Mentha viridis) essential oil on growth and aflatoxin production by Aspergillus flavus isolated from stored corn. J Food Saf 3:445–451
Harrison LR, Colvin BM, Greene JT, Newman LE, Cole JR (1990) Pulmonary edema and hydrothorax in swine produced by fumonisin B1 a toxic metabolite of Fusarium moniliforme. J Vet Diagn Inv 2:217–221
Isman MB, Miresmailli S, Machial C (2011) Commercial opportunities for pesticides based on plant essential oils in agriculture, industry and consumer products. Phytochem Rev 10(2):197–204
Kapros T, McDaniel SC (2009) Cytotoxicity of tea tree oil in tobacco cells. Allelopathy J 23 Print ISSN: 0971-4693. Online ISSN: 0973-5046
Kim JH, Campbell BC, Mahoney N, Chan KL, Molineaux RJ, Balajee A (2010) Augmenting the activity of antifungal agents against Aspergilli using structural analogues of benzoic acid as chemosensitizing agents. Fungal Biol 114:817–824
Kim JH, Mahoney N, Chan K, Molyneaux KL, Campbell BC (2006) Controlling food contaminating fungi by targeting antioxidant stress-response system with natural phenolic compounds. Appl Microbiol Biotechnol 70:735–739
Krieg B, Jansen M, Hahn K, Peisker H, Samajova O, Beck M, Braun S, Ulbrich A, Baluska F, Schulz M (2010) Cyclic monoterpenes mediated modulations of Arabidopsis thaliana phenotype. Plant Signal Behav 5(7):832–838
Kuete V, Alibert-Franco S, Eyong KO, Ngameni B, Folefoc GN, Nguemeving JR, Tangmouo JG, Fotso GW, Komguem J, Ouahouo BM, Bolla JM, Chevalier J, Ngadjui BT, Nkengfack AE, Pagès JM (2011) Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype. Int J Antimicrob Ag 37(2):156–161
Kumar A, Shukla R, Singh P, Anuradha, Dubey NK (2010) Efficacy of extract and essential oil of Lantana indica Roxb. against food contaminating moulds and aflatoxin B1 production. Int J Food Sci Technol 45:179–185
Kumar R, Dubey NK, Tiwari OP, Tripathi YB, Sinha KK (2007) Evaluation of some essential oils as botanical fungitoxicants for the protection of stored food commodities from fungal infestation. J Sci Food Agric 87:1737–1742
Lang G, Buchbauer G (2011) A review on recent research results (2008–2010) on essential oils as antimicrobials and antifungals. Flavour Frag J 27(1):13–39
Liu HY, Gao WW, Fan Y, Chen SL (2007) Inhibitory effect of essential oil from Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag against plant pathogenic fungi. Acta Phytopathol Sin 37:95–98
Ma X, Yang X, Zeng F, Yang L, Yu D, Ni H (2010) Physcion, a natural anthraquinone derivative, enhances the gene expression of leaf-specific thionin of barley against Blumeria graminis. Pest Manag Sci 66:718–724
Makarovsky I, Boguslavsky Y, Alesker M, Lellouche J, Banin E, Lellouche JP (2011) Novel triclosan-bound hybrid-silica nanoparticles and their enhanced antimicrobial properties. Advanced Func Mat 21(22):4295–4304
Magro A, Matos O, Bastos M, Carolino M, Lima A, Mexia A (2010) The use of essential oils to protect rice from storage fungi. In: 10th international working conference on stored product protection 542 Julius-Kühn-Archiv, p 425
Marasas WFO, Kellerman TS, Gelderblom WCA, Coetzer JAW, Thiel PG, van der Lugt JJ (1988) Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J Vet Res 55:197–203
Marìn S, Velluti A, Ramos AJ, Sanchis V (2004) Effect of essential oils on zearalenone and deoxynivalenol production by Fusarium graminearum in non-sterilized maize grain. Food Microbiol 21:313–318
Montes-Belmont R, Carvajal M (1998) Control of Aspergillus flavus in maize with plant essential oils and their components. J Food Prot 61:616–619
Morcia C, Spini M, Malnati M, Stanca Am, Terzi V (2011a) Essential oils and their components for the control of phytopathogenic fungi that affect plant health and agri-food quality and safety. In: Rai M, Chikindas M (eds) Natural antimicrobials for food safety and food quality. CABI Press, Oxford, pp 224–241, ISBN 978-1-84593-769-0
Morcia C, Malnati M, Terzi V (2012) In vitro antifungal activity of terpinen-4-ol, eugenol, carvone, 1,8-cineole (eucalyptol) and thymol against mycotoxigenic plant pathogens. Food Add Contam 29(3):415-422
Nguefack J, Leth V, Amvam Zollo PH, Mathur SB (2004) Evaluation of five essential oils from aromatic plants of Cameroon for controlling food spoilage and mycotoxin producing fungi. Int J Food Microbiol 94:329–334
Nogueira JHC, Goncalez E, Galletti SR, Facanali R, Marques MO, Felicio JD (2010) Ageatum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus. Int J Food Microbiol 137:55–60
Paranagama PA, Abeysekera KHT, Abeywickrama K, Nugaliyadde L (2003) Fungicidal and anti-aflatoxigenic effects of the essential oil of Cymbopogon citratus (DC.) Stapf. (lemongrass) against Aspergillus flavus Link. isolated from stored rice. LAM 37:86–90
Paster N, Menasherov M, Ravid U, Juven B (1995) Antifungal activity of oregano and thyme essential oils applied as fumigants against fungi attacking stored grain. J Food Sci 58:81–85
Rao A, Zhang Y, Muend S, Rao R (2010) Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway. Antimicrob Agents Chemother 54(12):5062–5069
Razzaghi-Abyaneh M, Yoshinari T, Shams-Ghahfarokhi M, Rezaee MB, Nagasawa H, Sakuda S (2007) Dillapiol and apiol as specific inhibitors of the biosynthesis of aflatoxin G 1 in Aspergillus parasiticus. Biosci Biotechnol Biochem 71:2329–2332
Reddy KRN, Reddy CS, Muralidharan K (2009) Potential of botanicals and biocontrol agents on growth and aflatoxin production by Aspergillus flavus infecting rice grains. Food Control 20:173–178
Ross RK, Yu MC, Henderson BE, Yuan J-M, Qian G-S, Tu J-T, Gao Y-T, Wogan GN, Groopman JD (1992) Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. The Lancet 339(8799):943–946
Sanchez-Gonzalez L, Vargas M, Gonzalez-Martinez C, Chiralt A, Chafer M (2011) Use of essential oils in bioactive edible coatings. Food Eng Rev 3:1–16
Schulz M, Kussmann P, Knop M, Kriegs B, Gresens F, Eichert T, Ulbrich A, Marx F, Fabricius H, Goldbach H, Noga G (2007) Allelopathic monoterpenes interfere with Arabidopsis thaliana cuticular waxes and enhance transpiration. Plant Signal Behav 2(4):231–239
Soliman KM, Badeaa RI (2002) Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem Toxicol 40:1669–1675
Soylu EM, Kurt S, Soylu S (2010) In vitro and in vivo antifungal activities of the essential oils of various plants against tomato grey mould disease agent Botrytis cinerea. Int J Food Microbiol 143:183–189
Srivastava B, Singh P, Shukla R, Dubey NK (2008) A novel combination of the essential oils of Cinnamomum camphora and Alpinia galanga in checking aflatoxin B1 production by a toxigenic strain of Aspergillus flavus. World J Microbiol Biotechnol 24:693–697
Straede A, Heinisch JJ (2007) Functional analyses of the extra- and intracellular domains of the yeast cell wall integrity sensors Mid2 and Wsc1. FEBS Lett 581:4495–4500
Teng Y, Yang QYuZ, Zhou G, Sun Q, Jin H, Hou T (2010) In vitro antimicrobial activity of the leaf essential oil of Spiraea alpina Pall. World J Microbiol Biotechnol 26:9–14
Tsuyuki R, Yoshinari T, Sakamoto N, Nagasawa H, Sakuda S (2011) Enhancement of Trichothecene Production in Fusarium graminearum by Cobalt Chloride. J Agric Food Chem 59:1760–1766
Vechet L, Burketova L, Sindelarova M (2009) A comparative study of the efficiency of several sources of induced resistance to powdery mildew (Blumeria graminis f. sp. tritici) in wheat under field conditions. Crop Prot 28:151–154
Velluti A, Sanchis V, Ramos AJ, Marín S (2004) Effect of essential oils of cinnamon, clove, lemongrass, oregano and palmarosa on growth of and fumonisin B1 production by Fusarium verticillioides in maize. J Sci Food Agric 84:1141–1146
Velluti A, Sanchis V, Ramos AJ, Egido J, Marìn S (2003) Inhibitory effect of cinnamon, clove, lemongrass, oregano and palmarose essential oils on growth and fumonisin B1 production by Fusarium proliferatum in maize grain. Int J Food Microbiol 89:145–154
Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D (2004) Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. The Am J Clin Nutr 80:1106–1122
Yaguchi A, Yoshinari T, Tsuyuki R, Takahashi H, Nakajima T, Sugita-Konishi Y, Nagasawa H, Sakuda S (2009) Isolation and identification of precocenes and piperitone from essential oils as specific inhibitors of thricothecene production by Fusarium graminearum. J Agric Food Chem 57:846–851
Yoshimura H, Sawai Y, Tamotsu S, Sakai A (2011) 1,8-cineole inhibits both proliferation and elongation of BY-2 cultured tobacco cells. J Chem Ecol 37:320–328
Yoshinari T, Yaguchi A, Takahashi-Ando N, Kimura M, Takahashi H, Nakajima T, Konichi Sugita, Nagasawa, Sakuda (2008) Spiroethers of German chamomile inhibit production of aflatoxin G and trichothecene mycotoxin by inhibiting cytochrome P450 monooxygenases involved in their biosynthesis. FEMS Microbiol Lett 284:184–190
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Morcia, C., Tumino, G., Terzi, V. (2013). Plant Bioactive Metabolites for Cereal Protection Against Fungal Pathogens. In: Razzaghi-Abyaneh, M., Rai, M. (eds) Antifungal Metabolites from Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38076-1_14
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DOI: https://doi.org/10.1007/978-3-642-38076-1_14
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