Abstract
Breast cancer (BC), which is one of the major malignant tumors, is a serious threat to women’s health with noticeably increased mortality. BC starts as a local disease, but it can metastasize to the other organs. Metastatic BC is the major difficult factor for treatment of advanced breast cancer. It suggests that early diagnosis for patients is of vital importance. Recent studies proved the involvement of microRNAs (miRNAs) in BC metastases. It was found that miRNAs contribute to oncogenesis by functioning as down-regulated tumor suppressors, and also can function as over-expressed oncogenes. The goal of this study is to construct a comprehensive BC metastasis related miRNAs regulatory network by collecting and integrating relevant information, the analysis results based on a Boolean network shows that it has great biological significances and provides new perspective for the later research.
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The paper is supported by the National Natural Science Foundation of China 60970005, 61272246.
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Zhao, W., Dong, Y. (2013). Research on Breast Cancer Metastasis Related miRNAs Network Based on a Boolean Network. In: Yin, Z., Pan, L., Fang, X. (eds) Proceedings of The Eighth International Conference on Bio-Inspired Computing: Theories and Applications (BIC-TA), 2013. Advances in Intelligent Systems and Computing, vol 212. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37502-6_91
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DOI: https://doi.org/10.1007/978-3-642-37502-6_91
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