Abstract
The 2003 Rotterdam consensus workshop concluded that polycystic ovarian syndrome (PCOS) is an ovarian dysfunction with hyperandrogenism and polycystic ovary (PCO) morphology. Therefore, no single diagnostic criterion (such as hyperandrogenism or PCO) is sufficient for clinical diagnosis (Rotterdam Group, 2004). PCOS is characterized by hyperandrogenism, anovulation, and an increased incidence of type 2 diabetes mellitus, insulin resistance, and coronary artery disease in mid-adult life. Women with PCOS have a higher risk of metabolic syndrome and its cardiovascular sequelae.
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Abbreviations
- IGFs:
-
Insulin-like growth factors
- PAI-1:
-
Plasminogen activator inhibitor type I
- PCOS:
-
Polycystic ovarian syndrome
References
Amowitz LL, Sobel BE (1999) Cardiovascular consequences of polycystic ovary syndrome. Endocrinol Metab Clin North Am 28:439–458
Atkin SL (2013) Cardiovascular disease in polycystic ovary syndrome. Clin Endocrinol (Oxf) 78:823–824
Bonadonna RC (1999) Insulin as a vascular hormone. Pract Diab Int 16(Suppl):S15–S18
Boyle J, Teede HJ (2012) Polycystic ovary syndrome, an update. Aust Fam Physician 41:752–756
Broekmans FJ, Fauser BC (2006) Diagnostic criteria for polycystic ovarian syndrome. Endocrine 30:3–11
Chang RJ, Katz SE (1999) Diagnosis of polycystic ovary syndrome. Endocrinol Metab Clin North Am 28:397–408
Clayton RN, Ogden V, Hodgkinson J, Worswick L, Rodin DA, Dyer S, Meade TW (1992) How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? Clin Endocrinol (Oxf) 37:127–134
Culiner A, Shippel S (1949) Virilism and theca cell hyperplasia of the ovary syndrome. J Obstet Gynaecol Br Commonw 56:439–445
Dahlgren E, Johansson S, Lindstedt G, Knutsson F, Odén A, Janson PO, Mattson LA, Crona N, Lundberg PA (1992) Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long term follow up focussing on natural history and circulating hormones. Fertil Steril 57:505–513
DeFronzo R, Brazilai N, Simonson D (1991) Mechanisms of metformin action in obese and lean non-insulin dependent diabetic subjects. J Clin Endocrinol Metab 73:1294–1301
Du Q, Wang YJ, Yang S, Wu B, Han P, Zhao YY (2012) A systematic review and meta-analysis of randomized controlled trials comparing pioglitazone versus metformin in the treatment of polycystic ovary syndrome. Curr Med Res Opin 28:723–730
Fantus I, Brosseau R (1986) Mechanism of action of metformin: insulin receptor and post receptor effects in vitro and in vivo. J Clin Endocrinol Metab 63:898–905
Farquhar CM, Birdsall M, Manning P, Mitchell JM, France JT (1994) The prevalence of polycystic ovaries on ultrasound scanning in a population of randomly selected women. Aust NZ J Obstet Gynecol 34:67–72
Graf MJ, Richards CJ, Brown V, Meissner L, Dunaif A (1990) The independent effects of hyperandrogenaemia, hyperinsulinaemia and obesity on lipid and lipoprotein profiles in women. Clin Endocrinol (Oxf) 33:119–131
Guzick DS, Talbott EO, Sutton-Tyrrell K, Herzog HC, Kuller LH, Wolfson SK Jr (1994) Carotid atherosclerosis in women with polycystic ovary syndrome: initial results from a case control study. Am J Obstet Gynecol 74:1224–1229
Holte J, Bergh T, Berne C, Wide L, Lithell H (1995) Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 80:2586–2593
Kannel WB, D’Agostino RB, Wilson PW, Belanger AJ, Gagnon DR (1990) Fibrinogen and the risk of cardiovascular disease: the Framingham experience. Am Heart J 120:672–676
Li XJ, Yu YX, Liu CQ, Zhang W, Zhang HJ, Yan B, Wang LY, Yang SY, Zhang SH (2011) Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta-analysis. Clin Endocrinol (Oxf) 74:332–339
Manson JE, Colditz GA, Stampfer MJ, Willett WC, Rosner B, Monson RR, Speizer FE, Hennekens CH (1996) A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med 322:882–889
Mitka M (2013) Panel recommends easing restrictions on rosiglitazone despite concerns about cardiovascular safety. JAMA 310:246–247
Panidis D, Tziomalos K, Papadakis E, Vosnakis C, Chatzis P, Katsikis I (2013) Lifestyle intervention and anti-obesity therapies in the polycystic ovary syndrome: impact on metabolism and fertility. Endocrine 44(3):583–590
Pasquale R, Casmirri F (1994) Body fat distribution has weight independent effects on clinical, hormonal and metabolic features in women with polycystic ovary syndrome. Metabolism 43:706–713
Pasquali R, Gambineri A (2013) Insulin sensitizers in polycystic ovary syndrome. Front Horm Res 40:83–102
Pasquali R, Gambineri A, Biscotti D, Vicennati V, Gagliardi L, Colitta D, Fiorini S, Cognigni GE, Filicori M, Morselli-Labate AM (2000) Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. J Clin Endocrinol Metab 85:2767–2774
Psaty BM, Furberg CD (2007) Rosiglitazone and cardiovascular risk. N Engl J Med 356:2522–2524
Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37:1595–1607
Rich-Edwards JW, Manson JE, Hennekens CH, Buring JE (1995) The primary prevention of coronary heart disease in women. N Engl J Med 332:1758–1766
Schneider DJ, Ricci MA, Taatjes DJ, Baumann PQ, Reese JC, Leavitt BJ, Absher PM, Sobel BE (1997) Changes in arterial expression of fibrinolytic system proteins in atherogenesis. Arterioscler Thromb Vasc Biol 17:3294–3301
Solorzano BCM, Beller JP, Abshire MY, Collins JS, McCartney CR, Marshall JC (2012) Neuroendocrine dysfunction in polycystic ovary syndrome. Steroids 77:332–337
Stankiewicz M, Norman R (2006) Diagnosis and management of polycystic ovary syndrome: a practical guide. Drugs 66:903–912
Stehouwer CDA (1999) Insulin resistance and hypertension. Pract Diab Int 16(Suppl):S19–S21
Stubbs SA, Webber LJ, Stark J, Rice S, Margara R, Lavery S, Trew GH, Hardy K, Franks S (2013) Role of insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries. J Clin Endocrinol Metab 98:3298–3305
Talbott E, Guzick D, Clerici A, Berga S, Detre K, Weimer K, Kuller L (1995) Coronary heart disease risk factors in women with polycystic ovary syndrome. Arterioscler Thromb Vasc Biol 15:821–826
Wenger NK, Speroff L, Packard B (1993) Cardiovascular health and disease in women. N Engl J Med 329:247–256
Wild RA (1997) Metabolic aspects of polycystic ovary syndrome. Semin Reprod Endocrinol 15:105–110
Further Reading
Dunaif A, Segal KR, Futterweit W, Dobrjansky A (1989) Profound peripheral insulin resistance, independent of obesity in polycystic ovary syndrome. Diabetes 38:1165–1174
Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T (1992) Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41:1257–1266
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:19–25
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Resmini, E., González Fernández, M. (2015). Hyperandrogenism and Polycystic Ovarian Disease: Impact on Vascular System. In: Lanzer, P. (eds) PanVascular Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37078-6_171
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DOI: https://doi.org/10.1007/978-3-642-37078-6_171
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