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Bioartifizielle Nervenimplantate und alternative Rekonstruktionsverfahren

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Zusammenfassung

Die Rekonstruktion durchtrennter peripherer Nerven stellt immer dann eine besondere Herausforderung dar, wenn eine spannungsfreie Koaptation der Nervenstümpfe nicht möglich ist. Nervendefekte von wenigen Millimetern Länge können in der Regel in End-zu-End-Nahttechnik koaptiert werden. Bei Nervendefekten mit überkritischer Länge führt die direkte Nervenkoaptation aufgrund der Spannung bzw. Zugkraft zu einer reaktiven Fibrose, die das Aussprossen regenerierender Axone behindert (Deumens et al. 2010). Deshalb bleibt die Rekonstruktion langstreckiger peripherer Nervenverletzungen eine große chirurgische Herausforderung. Ziel dabei ist es, regenerierende Nervenfasern mittels Leitstrukturen zu ihren ursprünglichen Zielgeweben zu „dirigieren“.

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Authors and Affiliations

  1. Klinik für Plastische Chirurgie, Hand- und Verbrennungschirurgie, Universitätsklinikum Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    Ahmet Bozkurt

  2. Institut für Neuroanatomie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Kirsten Haastert-Talini

Authors
  1. Ahmet Bozkurt
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  2. Kirsten Haastert-Talini
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Editors and Affiliations

  1. Universitätsklinik für Neurochirurgie, Evangelisches Krankenhaus - Carl von Ossietzky Universität, Oldenburg, Germany

    Thomas Kretschmer

  2. Neurochirurgische Klinik der Universität Ulm am Bezirkskrankenhaus Günzburg, Günzburg, Germany

    Gregor Antoniadis

  3. Schriesheim, Baden-Württemberg, Germany

    Hans Assmus

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Bozkurt, A., Haastert-Talini, K. (2014). Bioartifizielle Nervenimplantate und alternative Rekonstruktionsverfahren. In: Kretschmer, T., Antoniadis, G., Assmus, H. (eds) Nervenchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36895-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-36895-0_10

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