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Chemotaxis-Inspired Cellular Primitives for Self-Organizing Shape Formation

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Morphogenetic Engineering

Part of the book series: Understanding Complex Systems ((UCS))

Abstract

Motivated by the ability of living cells to form specific shapes and structures, we are investigating chemotaxis-inspired cellular primitives for self-organizing shape formation. This chapter details our initial effort to create Morphogenetic Primitives (MPs), software agents that may be programmed to self-organize into user-specified 2D shapes. The interactions of MPs are inspired by chemotaxis-driven aggregation behaviors exhibited by actual living cells. Cells emit a chemical into their environment. Each cell responds to the stimulus by moving in the direction of the gradient of the cumulative chemical field detected at its surface. The artificial chemical fields of individual MPs are explicitly defined as mathematical functions. Genetic programming is used to discover the chemical field functions that produce an automated shape formation capability. We describe the cell-based behaviors of MPs and a distributed genetic programming method that discovers the chemical fields needed to produce macroscopic shapes from simple aggregating primitives. Several examples of aggregating MPs demonstrate that chemotaxis is an effective paradigm for spatial self-organization algorithms.

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Acknowledgments

The authors would like to thank Manolya Eyiyurekli and Dr. Peter Lelkes, who significantly contributed to the development of the cell aggregation simulation system upon which our work builds. This research was supported by NSF grants CCF-0636323 and IIS-0845415.

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Authors and Affiliations

  1. Geometric Biomedical Computing Group, Department of Computer Science, Drexel University, Philadelphia, PA, 19104, USA

    Linge Bai & David E. Breen

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  1. Linge Bai
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  2. David E. Breen
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Correspondence to David E. Breen .

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Editors and Affiliations

  1. Institut des Systèmes Complexes, Paris Ile-de-France, Ecole Polytechnique, rue Lhomond 57-59, Paris, 75005, France

    René Doursat

  2. Binghamton University, Dept. Bioengineering, State University of New York, Binghamton, 13902-6000, New York, USA

    Hiroki Sayama

  3. Faculté des Sciences et Technologie, Lab. LACL-EA 4219, Université Paris-Est Créteil, avenue due Général de Gaulle 61, Créteil Cedex, 94010, France

    Olivier Michel

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Bai, L., Breen, D.E. (2012). Chemotaxis-Inspired Cellular Primitives for Self-Organizing Shape Formation. In: Doursat, R., Sayama, H., Michel, O. (eds) Morphogenetic Engineering. Understanding Complex Systems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33902-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-33902-8_9

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-33901-1

  • Online ISBN: 978-3-642-33902-8

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