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In Vitro Assessment of Biocompatibility for Orthodontic Materials

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Research Methods in Orthodontics

Abstract

Biocompatibility testing of novel biomaterials employs a wide spectrum of various in vivo and in vitro tests. As in vitro testing can respond to the urgent need for screening the huge amount of new materials produced nowadays, the present chapter is focusing on the cell-based assay systems used for such tests and introduces briefly the most common in vitro methods for the evaluation of the cell response to biomaterials, with an emphasis on testing of cell death and cell proliferation. Advantages and disadvantages of these methods, some hints for the setup of the tests, as well as, novel trends in assay methodologies are also here discussed.

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Authors and Affiliations

  1. Laboratory for Cell Proliferation and Ageing, Institute of Biology, National Centre for Scientific Research “Demokritos”, T. Patriarchou Grigoriou & Neapoleos, Athens, 15310, Greece

    Harris Pratsinis, Eleni Mavrogonatou, Adamantia Papadopoulou & Dimitris Kletsas

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  1. Harris Pratsinis
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  2. Eleni Mavrogonatou
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  3. Adamantia Papadopoulou
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  4. Dimitris Kletsas
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Correspondence to Dimitris Kletsas .

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Editors and Affiliations

  1. Center of Dental Medicine, Department of Orthodontics, University of Zurich, Plattenstraße 11, Zurich, 8032, Switzerland

    Theodore Eliades

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Pratsinis, H., Mavrogonatou, E., Papadopoulou, A., Kletsas, D. (2013). In Vitro Assessment of Biocompatibility for Orthodontic Materials. In: Eliades, T. (eds) Research Methods in Orthodontics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31377-6_3

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