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Systems Biology of Free Radicals and Antioxidants pp 1497–1522Cite as

Dietary Fatty Acids, Redox Signaling, and the Heart

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Abstract

In Western societies, cardiac disease (CD) remains the primary reason for unexpected morbidity and mortality. A frequent accomplice that participates in many cardiac disorders is the omnipresence of aberrant oxidative stress in such disease processes. As more research suggests nutritional factors have an important influence on this mechanism, there is an increasing realization that dietary fats modulate cardiac redox signaling. Fatty acids are the most energy dense macronutrients and therefore their signaling roles on cardiac cell types, during normal or disease physiology, may be crucial in strategizing therapeutic dietary interventions to attenuate cardiac oxidative damage. This chapter provides a summary of various dietary fatty acid classes, their impact on cardiac metabolism, and their role in either augmenting or attenuating cardiac oxidative stress.

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Acknowledgments

A Scholar award and Grant-In-Aids from the Canadian Diabetes Association and University Start-up Funds to SG supported this work. A Masters award from NSERC funds JB and AB is funded by a CIHR Doctoral Award.

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  1. Department of Biology, University of British Columbia-Okanagan, 3333 University Way, Kelowna, BC, Canada

    Julianne Beam, Amy Botta, Rebekah Barendregt & Sanjoy Ghosh

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  1. Julianne Beam
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Correspondence to Sanjoy Ghosh .

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  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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Beam, J., Botta, A., Barendregt, R., Ghosh, S. (2014). Dietary Fatty Acids, Redox Signaling, and the Heart. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_44

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