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Nanomedicines for Immunization and Vaccines

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Abstract

Immunization and treatment of infectious diseases is been extensively exploited to develop better and safe vaccines. The efforts have been made to improve the effectiveness of vaccines and for this reason nanomedicine emerges as the ultimate alternative. Most common infectious diseases, such as hepatite B virus (HBV), human immunodeficiency virus/ acquired immune deficiency syndrome (HIV/AIDS) malaria, human papillomavirus (HPV) and tuberculosis (TB), have aggressive and prolonged treatments, and for this purpose the development of novel therapeutic systems is a priority aiming at reducing cytotoxicity and drug resistance. Examples of these novel systems are solid lipid nanoparticles (SLN), polymeric, inorganic, metallic, magnetic, viral-based nanoparticles and dendrimers that have been received more attention for their proven efficiency in providing immunization, targeting and triggering antibody response at the cellular level. This review focuses on the efforts that have been made towards the development of novel approaches and also patented and marketed formulations of nanocarrier-based vaccine formulations.

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Authors and Affiliations

  1. Faculty of Health Sciences, Fernando Pessoa University (FCS-UFP), Rua Carlos da Maia, 296, P-4200-150, Porto, Portugal

    Joana F. Fangueiro & Eliana B. Souto

  2. Department of Biotechnological Processes, School of Chemical Engineering, State University of Campinas (UNICAMP), Campinas, 13083-970, Brazil

    Patrícia Severino

  3. Department of Endocrinology, Hospital de São João, University of Porto Medical School, Alameda Prof. Dr. Hernâni Monteiro, 4200-319, Porto, Portugal

    Selma B. Souto

  4. Institute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro (CGB-UTAD/IBB), 1013, P-5001-801, Vila Real, Portugal

    Eliana B. Souto

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  1. Joana F. Fangueiro
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    Eliana B. Souto

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Fangueiro, J.F., Severino, P., Souto, S.B., Souto, E.B. (2012). Nanomedicines for Immunization and Vaccines. In: Souto, E. (eds) Patenting Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29265-1_15

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