Definition
Animal models of lower gastrointestinal tract pain include graded colorectal distention, experimental colitis produced by intracolonic treatments (e.g., trinitrobenzene sulfonic acid) or ingestion of DSS (dextran sodium sulfate).
Characteristics
Methods
Distension of the Lower Gastrointestinal Tract
Distension of hollow organs has a long history in human medicine (e.g., see Ness and Gebhart 1990) and is rational because balloon distension reproduces the character and localization of pathological pain. Accordingly, graded colorectal distension (CRD) has been used to model in animals the study of lower gastrointestinal pain and hypersensitivity (Ness and Gebhart, 1987, 1988a, b; Traub et al. 1993; Al-Chaer et al. 1996, 1998). A device for controlling the pressure of intracolonic balloon distension in nonhuman animals has been described (Anderson et al. 1987). Humans report distinct sensations of pressure and of pain with...
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References
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Gebhart, G.F. (2013). Visceral Pain Model, Lower Gastrointestinal Tract Pain. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_4795
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DOI: https://doi.org/10.1007/978-3-642-28753-4_4795
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-28752-7
Online ISBN: 978-3-642-28753-4
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