Definition
Receptor trafficking is the constitutive or regulated movement of a receptor protein within the cell, whether between subcellular compartments or towards or away from plasma membranes. The presence of opioid receptors (OR) at the cell surface is essential for regulating opioid signal transduction and subsequent cellular functions. Following agonist activation, receptor internalization plays an important role in cellular responsiveness, by depleting the cell surface of receptors and contributing to the processes of receptor desensitizationand re-sensitization. Likewise, receptor insertion in plasma membranes through recycling of internalized receptors and/or targeting of reserve receptors from intracellular stores is critical for controlling the number of plasma membrane receptors accessible for stimulation and thereby for regulating various...
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Beaudet, A., Cahill, C.M., Morinville, A. (2013). Opioid Receptor Trafficking in Pain States. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_2962
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DOI: https://doi.org/10.1007/978-3-642-28753-4_2962
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