Skip to main content
SpringerLink
Log in

NSAIDs, Pharmacokinetics

  • Reference work entry
Encyclopedia of Pain

  • 887 Accesses

Synonyms

Pharmacokinetics of the NSAIDs; Plasma concentration versus time profiles

Definition

The pharmacokinetics describes the journey of a drug molecule through the body. The journey includes its release from the drug product, its absorption into the body system, for some substances its bio-activation via metabolism, the distribution to its site of action and back into the blood, and its elimination from the body either via transformation into inactive metabolites, which are then excreted, or direct excretion of the active entity. The goal of pharmacokinetics is to describe the time course of the drug concentrations in the organism in order to derive dosing regimens that provide most effective clinical drug actions with least side effects.

Characteristics

NSAIDs are mainly administered orally. Formulations for intravenous, intramuscular, topical, rectal, or intraocular administration are also available for some NSAIDs. The pharmacokinetics of the NSAIDs is best described by the...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 1,799.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahuja, N., Singh, A., & Singh, B. (2003). Rofecoxib: An update on physicochemical, pharmaceutical, pharmacodynamic and pharmacokinetic aspects. Journal of Pharmacy and Pharmacology, 55, 859–894.

    PubMed  CAS  Google Scholar 

  • Alsalameh, S., Burian, M., Mahr, G., et al. (2003). Review Article: The pharmacological properties and clinical use of valdecoxib, a New cyclo-oxygenase-2-selective inhibitor. Alimentary Pharmacology & Therapeutics, 17, 489–501.

    CAS  Google Scholar 

  • Bernareggi, A. (1998). Clinical pharmacokinetics of nimesulide. Clinical Pharmacokinetics, 35, 247–274.

    PubMed  CAS  Google Scholar 

  • Brocks, D. R., & Jamali, F. (1994). Etodolac clinical pharmacokinetics. Clinical Pharmacokinetics, 26, 259–274.

    PubMed  CAS  Google Scholar 

  • Brouwers, J. R., & de Smet, P. A. (1994). Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs. Clinical Pharmacokinetics, 27, 462–485.

    PubMed  CAS  Google Scholar 

  • Davies, N. M., & Skjodt, N. M. (2000). Choosing the right nonsteroidal anti-inflammatory drug for the right patient: A pharmacokinetic approach. Clinical Pharmacokinetics, 38, 377–392.

    PubMed  CAS  Google Scholar 

  • Davies, N. M., & Watson, M. S. (1997). Clinical pharmacokinetics of sulindac. A dynamic old drug. Clinical Pharmacokinetics, 32, 437–459.

    PubMed  CAS  Google Scholar 

  • Geisslinger, G., Lotsch, J., Menzel, S., et al. (1994). Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers. British Journal of Clinical Pharmacology, 37, 392–394.

    PubMed  CAS  Google Scholar 

  • Helleberg, L. (1981). Clinical pharmacokinetics of indomethacin. Clinical Pharmacokinetics, 6, 245–258.

    PubMed  CAS  Google Scholar 

  • Hinz, B., Rau, T., Auge, D., et al. (2003). Aceclofenac spares cyclooxygenase-1 as a result of limited but sustained biotransformation to diclofenac. Clinical Pharmacology and Therapeutics, 74, 222–235.

    PubMed  CAS  Google Scholar 

  • Kauffman, R. E., Lieh-Lai, M. W., Uy, H. G., et al. (1999). Enantiomer-selective pharmacokinetics and metabolism of ketorolac in children. Clinical Pharmacology and Therapeutics, 65, 382–388.

    PubMed  CAS  Google Scholar 

  • Mroszczak, E., Combs, D., Chaplin, M., et al. (1996). Chiral kinetics and dynamics of ketorolac. The Journal of Clinical Pharmacology, 36, 521–539.

    CAS  Google Scholar 

  • Needs, C. J., & Brooks, P. M. (1985). Clinical pharmacokinetics of the salicylates. Clinical Pharmacokinetics, 10, 164–177.

    PubMed  CAS  Google Scholar 

  • Olkkola, K. T., Brunetto, A. V., & Mattila, M. J. (1994). Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents. Clinical Pharmacokinetics, 26, 107–120.

    PubMed  CAS  Google Scholar 

  • van der Marel, C. D., Anderson, B. J., Romsing, J., et al. (2004). Diclofenac and metabolite pharmacokinetics in children. Paediatric Anaesthesia, 14, 443–451.

    PubMed  Google Scholar 

  • Warner, T. D., & Mitchell, J. A. (2004). Cyclooxygenases: New forms, new inhibitors, and lessons from the clinic. The FASEB Journal, 18, 790–804.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Clinical Pharmacology, Pharmaceutical Center Frankfurt, Johann Wolfgang Goethe University, Frankfurt, Germany

    Joern Loetsch & Bruno Oertel

Authors
  1. Joern Loetsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bruno Oertel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Joern Loetsch .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA

    Gerald F. Gebhart

  2. Physiologisches Institut der, Universität Würzburg, Würzburg, Germany

    Robert F. Schmidt

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Loetsch, J., Oertel, B. (2013). NSAIDs, Pharmacokinetics. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_2853

Download citation

Publish with us

Policies and ethics

Search

Navigation