Definition
The thalamus is the major relay structure in the forebrain for noxious and non-noxious sensory inputs. In the case of noxious stimuli, the thalamus distributes the incoming information to other specific cortical areas for proper processing of their discriminative, cognitive, and affective components. Recent neuroimaging techniques can effectively detect transient thalamic neuronal activation following the application of experimental stimuli that artificially replicate painful conditions in humans.
Characteristics
Thalamic neuronal activation is frequently observed in functional neuroimaging studies following experimental pain. Through the use of neuroimaging techniques, the role of the thalamus has been gradually dissected in the nociceptive CNS network. Under those studies, experimental pain resultant of different noxious stimuli has revealed a pattern of thalamic activation that depends on the type of stimuli...
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References
Bantick, S. J., Wise, R. G., Ploghaus, A., et al. (2002). Imaging how attention modulates pain in humans using functional MRI. Brain, 125, 310–319.
Casey, K. L., Svensson, P., Morrow, T. J., et al. (2000). Selective opiate modulation of nociceptive processing in the human brain. Journal of Neurophysiology, 84, 525–533.
Craig, A. D. (2002). How do you feel? Interoception: The sense of the physiological condition of the body. Nature Reviews. Neuroscience, 3, 655–666.
Creac’h, C., Henry, P., Caille, J. M., et al. (2000). Functional MR imaging analysis of pain-related brain activation after acute mechanical stimulation. AJNR. American Journal of Neuroradiology, 21, 1402–1406.
DaSilva, A. F., Becerra, L., Makris, N., et al. (2002). Somatotopic activation in the human trigeminal pain pathway. The Journal of Neuroscience, 22, 8183–8192.
DaSilva, A. F., Tuch, D. S., Wiegell, M. R., et al. (2003). Diffusion tensor imaging – A primer on diffusion tensor imaging of anatomical substructure. Neurosurgical Focus, 15, 1–4.
DaSilva, A. F., Volz, M. S., Bikson, M., & Fregni, F. (2011). Electrode positioning and montage in transcranial direct current stimulation. Journal of Visualized Experiments, 51, e2744.
DaSilva, A. F., Mendonca, M. E., Zaghi, S., Lopes, M., Dos Santos, M. F., Spierings, E. L., et al. (2012). tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine. Headache, 52, 1283–1295. doi:10.1111/j.1526 4610.2012.02196.x. (see http://www.ncbi.nlm.nih.gov/pubmed/22512348).
Derbyshire, S. W., Jones, A. K., Collins, M., et al. (1999). Cerebral responses to pain in patients suffering acute post-dental extraction pain measured by positron emission tomography (PET). European Journal of Pain, 3, 103–113.
Di Piero, V., Fiacco, F., Tombari, D., et al. (1997). Tonic pain: A SPET study in normal subjects and cluster headache patients. Pain, 70, 185–191.
DosSantos, M. F., Love, T., Martikainen, I. K., Nascimento, T. D., Fregni, F., Cummiford, C. M., et al. (2012). Immediate effect of tDCS on the μ-opioid system of a chronic pain patient. Front Psychiatry, 3, 93.
Faymonville, M. E., Roediger, L., Del Fiore, G., et al. (2003). Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis. Brain Research. Cognitive Brain Research, 17, 255–262.
Garcia-Larrea, L., Brousolle, E., Cezanne-Bert, G., Maugiere, F., et al. (1997). P 300 and frontal executive functions: application of a dual-task paradigm in normal subjects and patients with Parkinson‘s disease and progressive supranuclear palsy. Electroencephalography and Clinical Neurophysiology, 103, 148.
Garcia-Larrea, L., Peyron, R., Mertens, P., Gregoire, M. C., Lavenne, F., Le Bars, D., Convers, P., Mauguiere, F., Sindou, M., Laurent, B., et al. (1999). Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study. Pain, 83, 259–273.
Gracely, R. H., Petzke, F., Wolf, J. M., et al. (2002). Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis and Rheumatism, 46, 1333–1343.
Hsieh, J. C., Belfrage, M., Stone-Elander, S., et al. (1995). Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain, 63, 225–236.
Iadarola, M. J., Berman, K. F., Zeffiro, T. A., et al. (1998). Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET. Brain, 121, 931–947.
Kwiatek, R., Barnden, L., Tedman, R., et al. (2000). Regional cerebral blood flow in fibromyalgia: Single-photon-emission computed tomography evidence of reduction in the pontine tegmentum and thalami. Arthritis and Rheumatism, 43, 2823–2833.
Lorenz, J., Minoshima, S., & Casey, K. L. (2003). Keeping pain out of mind: The role of the dorsolateral prefrontal cortex in pain modulation. Brain, 126, 1079–1091.
Paulson, P. E., Minoshima, S., Morrow, T. J., et al. (1998). Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans. Pain, 76, 223–229.
Polania, R., Paulus, W., & Nitsche, M. A. (2012). Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation. Human Brain Mapping, 33(10), 2499–2508.
Strafella, A. P., Vanderwerf, Y., & Sadikot, A. F. (2004). Transcranial magnetic stimulation of the human motor cortex influences the neuronal activity of the subthalamic nucleus. European Journal of Neuroscience, 20, 2245–2249.
Svensson, P., Minoshima, S., Beydoun, A., et al. (1997). Cerebral processing of acute skin and muscle pain in humans. Journal of Neurophysiology, 78, 450–460.
Wiegell, M. R., Tuch, D. S., Larsson, H. B., et al. (2003). Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging. NeuroImage, 19, 391–401.
Zubieta, J. K., Smith, Y. R., Bueller, J. A., et al. (2002). mu-Opioid receptor-mediated antinociceptive responses differ in men and women. The Journal of Neuroscience, 22, 5100–5107.
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DaSilva, A.F.M., Hadjikhani, N. (2013). Human Thalamic Response to Experimental Pain (Neuroimaging). In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_1792
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DOI: https://doi.org/10.1007/978-3-642-28753-4_1792
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