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Researches on Application of Stem Cell Therapy in Exercise-Induced Spinal Cord Injury Recovery

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Part of the book series: Advances in Intelligent and Soft Computing ((AINSC,volume 119))

Abstract

Exercise-induced spinal cord injury can easily cause hypoaesthesia, hypokinesia and also irreversible damages to reflection function and bring huge burdens both to patients and the whole society. Currently, it is difficult to find one effective therapy for exercise-induced spinal cord injury. Stem cell technology progress has created good opportunities for exercise-induced spinal cord injury recovery. Through searching the research literatures related to stem cell technology and its application in exercise-induced spinal cord injury prevention and treatment, this thesis is aimed to analyze and explore stem cell therapy application in exercise-induced spinal cord injury and to discuss stem cell transplantation applications in spinal cord injury recovery, stem cell neurotrophic factor’s role in spinal cord injury recovery and researches on stem cell therapy of gene modification as well as spinal cord injury recovery, so as to provide scientific proof and theory basis for the repair and treatment of exercise-induced spinal cord injury. Stem cell’s such properties as transplantation, migration, self-renewal and multi-differentiation make it inevitable for stem cell to be applied into exercise-induced spinal cord injury recovery.

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References

  1. Luo, J.D., Liu, R.: Bone marrow mesenchymal stem cells and treating spinal cord injury. Journal of Clinical Rehabilitative Tissur Engineering Research 14(36), 6813–6816 (2010)

    MathSciNet  Google Scholar 

  2. Tian, Z.J., Wang, Y.H.: Application and prospect of stem cell technology in sports medicine. Journal of Beijing Sport University 28(4), 503–506 (2005)

    MathSciNet  Google Scholar 

  3. Zhen, Q.X., Hong, Y.: Characteristics of sports-related spinal cord injury: 38 cases report. Chin. J. Rehabil. Theory Pract. 16(1), 66–67 (2010)

    Google Scholar 

  4. Ji, Y., Yun, X.: Changes of cardiopulmonary function of patients with spinal cord injury in different lesion levels in exercise testing. Chin. J. Rehabil. Theory Pract. 13(10), 915–916 (2007)

    Google Scholar 

  5. Zhi, X.D., Lü, G.: Cotransplantation of rat bone marrow mesenchymal stem cells and schwann’s cells for treating spinal cord injury. Journal of Clinical Rehabilitative Tissur Engineering Research 12(16), 3015–3018 (2008)

    Google Scholar 

  6. Katoh, S., Shingu, H., Ikata, T., et al.: Sports-related spinal cord injury in Japan (from the nationwide spinal cord injury registry between 1990 and 1992). Spinal Cord 34(7), 416–421 (1996)

    Article  Google Scholar 

  7. Achery, A., Hagel, B.E., Provvidenza, C., et al.: An international review of head and spinal cord injuries in alpine skiing and snowboarding. Injury Prev. 13(6), 368–375 (2007)

    Article  Google Scholar 

  8. Silva, P., Vaidyanathan, S., Kumar, B.N., et al.: Two case reports of cervical spinal cord injury in football (soccer) players. Spinal Cord 44, 383–385 (2006)

    Article  Google Scholar 

  9. Bai, H.L., Wu, S.F., Qian, C.R., et al.: Early change of the stem cells translated through the cerebrospinal fluid on the injured spinal cord. Chinese Journal of Practical Aesthetic and Plastic Surgery 16(4), 195–198 (2005)

    Google Scholar 

  10. Zhai, C.J., Cao, Y.D., Liu, S.A., et al.: Functional Recovery of Rats with Spinal Cord Injury Treated by Neural Stem Cell Transplantation Combined with Low Intensity Ultrasound. Chinese J. Ultrasound med. 24(11), 976–981 (2008)

    Google Scholar 

  11. Liang, P., Jin, L.H., Liang, T., et al.: Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats. China Med. J.(Engl.) 119(6), 1331–1338 (2006)

    Google Scholar 

  12. Pallini, R., Vitiani, L.R., Bez, A., et al.: Homologous transplantation of neural stem cells to the injured spinal cord of mice. Neurosurgery 57(5), 1014–1025 (2005)

    Article  Google Scholar 

  13. Kang, D.Z., Lin, J.H., Yu, L.H., et al.: Role of bone marrow stem cells by vein transplantation in repair of spinal cord injury in rat. Chin. J. Neuromed. 5(1), 1117–1121 (2006)

    Google Scholar 

  14. Zhi, C.S., Xie, L.: Effects of mesenchymal stem cells transplantation on the brain-derived neurotrophic factor and growth associated protein-43 after the spinal cord injury of tats. Orthopedic Journal of China 17(18), 1404–1406 (2009)

    Google Scholar 

  15. Zhang, Y.H., Grant, D.: Nicol NGF-mediated sensitization of the excitability of rat sensory neurons is pervented by a blocking antibody to the p75 neurotrophin receptor. Neurosci. Lett. 366(2), 187–192 (2004)

    Article  Google Scholar 

  16. Lu, P., Jones, L.L., Tuszynski, M.: BDNF-expressing marrow stromal cells support extensive axonal growth ai sites of spinal cord injury. Exp. Neurol. 191(2), 344–360 (2005)

    Article  Google Scholar 

  17. Neuhuber, B., Timothy Himes, B., Shumsky, J.S., et al.: Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res. 1035(1), 73–85 (2005)

    Article  Google Scholar 

  18. Ankeny, D.P., McTigue, D.M., Jakeman, L.: Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp. Neurol. 190(1), 17–31 (2004)

    Article  Google Scholar 

  19. Chen, X.C., Yang, S.: The efects of mesenchymal stem cells transplantation on the brain·derived neurotrophic factors after the spinal cord injury. China Prac. Med. 3(6), 22–23 (2008)

    Google Scholar 

  20. Wu, Z.X., Ren, L.: The experiment of the efect of exogenous BDNF combined with bone mesenchymal stem cells in promoting axon recovery after spinal cord injury in adult rats. Shanxi Med. J. 37(12), 1077–1079 (2008)

    Google Scholar 

  21. Wang, J.F., Fang, H., Luo, Y.X., et al.: Efects of co-grafts of bone marrow stromal cells and nerve growth factor suspension on repair of spinal cord injury. Chin. J. Orthop. Trauma 8(8), 764–768 (2006)

    Google Scholar 

  22. Wu, Q.L., Li, Q.G., Liu, K.: Stem cell transplantation for treatment of spinal cord injury. Journal of Clinical Rehabilitative Tissue Engineering Research 12(12), 2343–2346 (2008)

    Google Scholar 

  23. Zhang, L., Gu, S., Zhao, C., et al.: Combined treatment of neurotro-phin 23 gene and neural stem cells is prop itious to functional recovery after spinal cord injury. Cell Trans plant 16(5), 475–481 (2007)

    Google Scholar 

  24. Kegami, T., Nakamura, M., Yaman, J., et al.: Chondroitinase ABC combined with neural stem progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protrin-43-lxsitive fibers after rat spinal cord injury. Neurosci. 22(12), 3036–3046 (2005)

    Google Scholar 

  25. Castellanos, D.A., Tsoulfas, P., Frydel, B.: Over expression enhances survival and migration of neural stem cell transplants in the rat spinal cord. Cell Transplant 11(3), 297–307 (2002)

    Google Scholar 

  26. Kong, L.S., Yu, R.T., Nie, D.L., et al.: Effect of transplantation of HIF-1a gene-modified neural stem cells on expressions of neurfilament 200 and GFAP in injured spinal cord tissues in rats. Chin. J. Clin. Neurosurg. 14(8), 483–487 (2009)

    Google Scholar 

  27. Guo, J.S., Zeng, Y.S., Li, H.B., et al.: NT-3 genetically modified schwann cells promote grafted neural stem cells differentiate into neuron-like cells in the injured spinal cord. Acta Anatomica Sinica 36(6), 577–581 (2005)

    Google Scholar 

  28. Guo, J.S., Zeng, Y.S., Li, H.B., et al.: Combinative grafting neural stem cells and NT-3 genetically modified Schwann cells to promote the injured neurons’ survival and axonal regeneration of the ransected spinal cord rat. Chin. J. Microsurg. 28(4), 337–339 (2005)

    Google Scholar 

  29. Zhang, W., Zeng, Y.S., Zhang, X.B., et al.: Research on bone warrow mesenchymal stem cells modified by NT-3 gene and pretreated with retinoic acid to differentiate into neuron-like cells in the injured site of spinal cord. Acta Anatomica Sinica 39(1), 12–17 (2008)

    Google Scholar 

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Honglin, Q., Liu, R. (2012). Researches on Application of Stem Cell Therapy in Exercise-Induced Spinal Cord Injury Recovery. In: Zhang, T. (eds) Future Computer, Communication, Control and Automation. Advances in Intelligent and Soft Computing, vol 119. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25538-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-25538-0_15

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25537-3

  • Online ISBN: 978-3-642-25538-0

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