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Tropic Orientation Responses of Pathogenic Fungi

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Morphogenesis and Pathogenicity in Fungi

Part of the book series: Topics in Current Genetics ((TCG,volume 22))

Abstract

Cellular orientation allows growth, differentiation and behaviour to respond to vectorial cues generated in the environment and in relation to cells of the same organisms or different organisms that exist in proximity to one another. In the case of fungal pathogens, the orientation of hyphae may allow the fungus to detect a host and to make strategic penetrations at points of weakness on the host surface. Within a host, tropic orientation may facilitate colonisation, ramification and dispersal within the host tissues. To achieve this, cells have to be able to coordinate their cell cycles, growth and expansion of their margins with directional growth responses. In this chapter, we review the tropic orientation responses of fungi and, with an emphasis on fungal pathogenesis, discuss and speculate on the underlying molecular mechanisms that regulate cellular tropisms. Examples are taken across the fungal kingdom, including from work on saprophytes, plant and animal pathogens, to construct a working model that speculates how a wide range of tropisms may be controlled by a more-or-less common tropic mechanism that regulates the orientation of the hyphal tip.

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Acknowledgements

Our research in this area has been funded by the MRC, BBSRC, Wellcome trust and Royal Society. AB is the recipient of an MRC New Investigator Award and a Royal Society University Research Fellowship.

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  1. Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, UK

    Alexandra Brand & Neil A. R. Gow

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  1. Alexandra Brand
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Correspondence to Neil A. R. Gow .

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  1. , Department of Microbial Biotechnology, Centro Nacional de Biotecnologia CSIC, Madrid, 28049, Spain

    José Pérez-Martín

  2. , Department of Genetics, University of Cordoba, Cordoba, 14071, Spain

    Antonio Di Pietro

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Brand, A., Gow, N.A.R. (2012). Tropic Orientation Responses of Pathogenic Fungi. In: Pérez-Martín, J., Di Pietro, A. (eds) Morphogenesis and Pathogenicity in Fungi. Topics in Current Genetics, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22916-9_2

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