Zusammenfassung
Weißes Fettgewebe ist der größte Energiespeicher des Körpers. Die Entwicklung dieses spezialisierten Bindegewebes in der Evolution der Wirbeltiere ermöglichte die Unabhängigkeit von ständiger Nahrungszufuhr. Weißes Fettgewebe dient als Baufett, zur Polsterung und Isolierung, und als Energiespeicher. Es reagiert außerordentlich plastisch auf das Energieangebot des Körpers und steuert neben dem Energiestoffwechsel auch die Immun- und Reproduktionsfunktion der Säugetiere. Trotz einheitlicher Morphologie nehmen Adipozyten je nach Lokalisation im Körper verschiedene Funktionen wahr. Diese regionalen Unterschiede werden in diesem Kapitel detailliert beschrieben.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Abel ED, Peroni O, Kim JK et al. (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409:729–733
Ali AH, Koutsari C, Mundi M et al. (2011) Free fatty acid storage in human visceral and subcutaneous adipose tissue: role of adipozyte proteins. Diabetes 60:2300–2307
Arner P, Bernard S, Salehpour M et al. (2011) Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478:110–113
Astrup A, Bulow J, Christensen NJ, Madsen J (1984) Ephedrine-induced thermogenesis in man: no role for interscapular brown adipose tissue. Clin Sci (Lond) 66:179–186
Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmuller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J (2011) Brown adipose tissue activity controls triglyzeride clearance. Nat Med 17:200–205
Belanger C, Hould FS, Lebel S et al. (2006) Omental and subcutaneous adipose tissue steroid levels in obese men. Steroids 71:674–682
Birkenfeld AL, Budziarek P, Boschmann M et al. (2008) Atrial natriuretic peptide induces postprandial lipid oxidation in humans. Diabetes 57:3199–3204
Blüher M, Michael MD, Peroni OD et al. (2002) Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 3:25–38
Blüher M, Brennan AM, Kelesidis T et al. (2007) Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care 30:280–285
Bobbert T, Rochlitz H, Wegewitz U et al. (2005) Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 54:2712–2719
Boden G, Duan X, Homko C et al. (2008) Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57:2438–4244
Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessi-Fulgheri P, Zhang C, Takahashi N, Sarzani R, Collins S (2012) Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipozytes. J Clin Invest
Boschmann M, Engeli S, Adams F et al. (2005) Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives. Hypertension 46:130–136
Boschmann M, Engeli S, Adams F et al. (2006) Influences of AT1 receptor blockade on tissue metabolism in obese men. Am J Physiol Regul Integr Comp Physiol 290:R219–R223
Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM (2012) A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–468
Bujalska IJ, Quinkler M, Tomlinson JW et al. (2006) Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipozytes. J Mol Endocrinol 37:327–340
Cancello R, Henegar C, Viguerie N et al. (2005) Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 54:2277–2286
Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84:277–359
Chance B, Williams GR (1955) A simple and rapid assay of oxidative phosphorylation. Nature 175(4469):1120–1121
Charrière G, Cousin B, Arnaud E et al. (2003) Preadipozyte conversion to macrophage. Evidence of plasticity J Biol Chem 278:9850–9855
Christensen CR, Clark PB, Morton KA (2006) Reversal of hypermetabolic brown adipose tissue in F-18 FDG PET imaging. Clin Nucl Med 31:193–196
Cianflone K, Xia Z, Chen LY (2003) Critical review of acylation-stimulating protein physiology in humans and rodents. Biochim Biophys Acta 1609:127–143
Cinti S (2005) The adipose organ. Prostaglandins Leukot Essent Fatty Acids 73:9–15
Cinti S (1999) The adipose organ. Editrice, Kurtis
Cinti S, Mitchell G, Barbatelli G et al. (2005) Adipozyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347–2355
Crandall DL, Hausman GJ, Kral JG (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4:211–232
Cunningham S, Leslie P, Hopwood D, Illingworth P, Jung RT, Nicholls DG, Peden N, Rafael J, Rial E. 1985. The characterization and energetic potential of brown adipose tissue in man. Clin Sci (Lond) 69:343–348
Curat CA, Miranville A, Sengenès C et al. (2004) From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipozytes. Diabetes 53:1285–1292
Curat CA, Wegner V, Sengenès C et al. (2006) Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia 49:744–747
Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509–1517
Daval M, Foufelle F, Ferre P (2006) Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574:55–62
Drubach LA, Palmer EL III, Connolly LP, Baker A, Zurakowski D, Cypess AM (2011) Pediatric brown adipose tissue: detection, epidemiology, and differences from adults. J Pediatr 159:939–944
Dubois SG, Heilbronn LK, Smith SR (2006) Decreased expression of adipogenic genes in obese subjects with type 2 diabetes. Obesity 14:1543–1552
Ellingsgaard H, Hauselmann I, Schuler B et al. (2011) Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med 17:1481–1489
Enerback S (2010) Human brown adipose tissue. Cell Metab 11:248–252
Engeli S, Feldpausch M, Gorzelniak K et al. (2003) Association between adiponectin and mediators of inflammation in obese women. Diabetes 52:942–947
Engeli S, Schling P, Gorzelniak K et al. (2003) The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome? Int J Biochem Cell Biol 35:807–825
Engeli S, Böhnke J, Gorzelniak K et al. (2005) Weight loss and the renin-angiotensin-aldosterone system. Hypertension 45:356–362
Fain JN, Madan AK, Hiler ML et al. (2004) Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipozytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145:2273–2282
Fain JN, Madan AK (2005) Insulin enhances vascular endothelial growth factor, interleukin-8, and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipozytes. Metabolism 54:220–226
Farmer SR (2006) Transcriptional control of adipozyte formation. Cell Metab 4:263–273
Fischer-Posovszky P, Wang QA, Asterholm IW et al. (2011) Targeted deletion of adipozytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages. Endocrinology 152:3074–3081
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM (2012) FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26:271–281
Fontana L, Eagon JC, Trujillo ME et al. (2007) Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56:1010–1013
Foster DO, Frydman ML (1979) Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. Can J Physiol Pharmacol 57:257–270
Fried SK, Russell CD, Grauso NL, Brolin RE (1993) Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J Clin Invest 92:2191–2198
Furuhashi, M, Tuncman, G, Gorgun et al. (2007) Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447:959–965
Garg A (2000) Lipodystrophies. Am J Med 108:143–152
Gibson WT, Farooqi IS, Moreau M et al. (2004) Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. J Clin Endocrinol Metab 89:4821–4826
Gronthos S, Franklin DM, Leddy HA et al. (2001) Surface protein characterization of human adipose tissue-derived stromal cells. J Cell Physiol 189:54–63
Hansen JC, Gilman AP, Odland JO (2010) Is thermogenesis a significant causal factor in preventing the “globesity” epidemic? Med Hypotheses 75:250–256
Hany TF, Gharehpapagh E, Kamel EM, Buck A, Himms-Hagen J, von Schulthess GK (2002) Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region. Eur J Nucl Med Mol Imaging 29:1393–1398
Harmelen van V, Röhrig K, Hauner H (2004) Comparison of proliferation and differentiation capacity of human adipozyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects. Metabolism 53:632–637
Hattori Y, Akimoto K, Gross SS et al. (2005) Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats. Diabetologia 48:1066–1074
Haufe S, Engeli S, Kast P et al. (2011) Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology 53:1504–1514
Hauner H, Entenmann G, Wabitsch M et al. (1989) Promoting effect of glucocorticoids on the differentiation of human adipozyte precursor cells cultured in a chemically defined medium. J Clin Invest 84:1663–1670
Hauner H, Much D, Vollhardt C et al. (2012) Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. Am J Clin Nutr 95:383–394
Heaton JM (1972) The distribution of brown adipose tissue in the human. J Anat 112:35–39
Heldmaier G (1971) Zitterfreie Wärmebildung und Körpergröße bei Säugetieren. Zeitschrift für Vergleichende Physiologie 73:222–248
Hida K, Wada J, Eguchi J et al. (2005) Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 102:10610–10615
Hondares E, Rosell M, Diaz-Delfin J, Olmos Y, Monsalve M, Iglesias R, Villarroya F, Giralt M (2011) Peroxisome proliferator-activated receptor alpha (PPARalpha) induces PPARgamma coactivator 1alpha (PGC-1alpha) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16. J Biol Chem 286:43112–43122
Hotamisligil GS, Johnson RS, Distel RJ et al. (1996) Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipozyte fatty acid binding protein. Science 274:1377–1379
Hube F, Hauner H (1999) The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance? Horm Metab Res 31:626–631
Isakson P, Hammarstedt A, Gustafson B, Smith U (2009) Impaired preadipozyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes 58:1550–1557
Janke J, Engeli S, Gorzelniak K et al. Mature adipozytes inhibit in vitro differentiation of human preadipozytes via angiotensin type 1 receptors. Diabetes 51:1699–1707
Javor ED, Cochran EK, Musso C et al. (2005) Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes 54:1994–2002
Johnson F, Mavrogianni A, Ucci M, Vidal-Puig A, Wardle J (2011) Could increased time spent in a thermal comfort zone contribute to population increases in obesity? Obes Rev 12:543–551
Jordan J, Tank J, Stoffels M et al. (2001) Interaction between beta-adrenergic receptor stimulation and nitric oxide release on tissue perfusion and metabolism. J Clin Endocrinol Metab 86:2803–2810
Kadowaki T, Yamauchi T, Kubota N et al. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784–1792
Karpe F, Olivecrona T, Olivecrona G et al. (1998) Lipoprotein lipase transport in plasma: role of muscle and adipose tissues in regulation of plasma lipoprotein lipase concentrations. J Lipid Res 39:2387–2393
Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89:2548–2556
Khan T, Muise ES, Iyengar P et al. (2009) Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29:1575–1591
Kingma B, Frijns A, van Marken LW (2012) The thermoneutral zone: implications for metabolic studies. Front Biosci (Elite Ed) 4:1975–1985
Klingenspor M (2003) Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88:141–148
Klingenspor M, Fromme T (2012) Brown adipose tissue. In: Symonds ME (ed), Adipose tissue biology. 1st ed. Springer, New York Dordrecht Heidelberg London. 39–79
Klingenspor M, Meywirth A, Stohr S, Heldmaier G (1994) Effect of unilateral surgical denervation of brown adipose tissue on uncoupling protein mRNA level and cytochrom-c-oxidase activity in the Djungarian hamster. J Comp Physiol [B] 163:664–670
Klöting N, Graham TE, Berndt J et al. (2007) Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab 6:79–87
Kovsan J, Blüher M, Tarnovscki T et al. (2011) Altered autophagy in human adipose tissues in obesity. J Clin Endocrinol Metab 96:E268–277
Lafontan M (2005) Fat cells: afferent and efferent messages define new approaches to treat obesity. Annu Rev Pharmacol Toxicol 45:119–146
Langin D, Dicker A, Tavernier G et al. (2005) Adipozyte lipases and defect of lipolysis in human obesity. Diabetes. 54:3190–3197
Langin D (2006) Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res 53:482–491
Large V, Peroni O, Letexier D et al. (2004) Metabolism of lipids in human white adipozyte. Diabetes Metab 30:294–309
Lee P, Greenfield JR, Ho KK, Fulham MJ (2010) A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 299:E601–E606
Levine JA, Jensen MD, Eberhardt NL, O’Brien T (1998) Adipozyte macrophage colony-stimulating factor is a mediator of adipose tissue growth. J Clin Invest 101:1557–1564
Marken L van WD, Schrauwen P (2011) Implications of nonshivering thermogenesis for energy balance regulation in humans. Am J Physiol Regul Integr Comp Physiol 301:R285–R296
Marken Lichtenbelt van WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500–1508
Massiéra F, Bloch-Faure M, Ceiler D et al. (2001) Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 15:2727–2729
Masuzaki H, Paterson J, Shinyama H et al. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166–2170
McQuaid SE, Humphreys SM, Hodson L et al. (2010) Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids. Diabetes 59:2465–2473
McQuaid SE, Hodson L, Neville MJ et al. (2011) Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes 60:47–55
Merklin RJ (1974) Growth and distribution of human fetal brown fat. Anat Rec 178:637–645
Meyer CW, Willershauser M, Jastroch M, Rourke BC, Fromme T, Oelkrug R, Heldmaier G, Klingenspor M (2010) Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice. Am J Physiol Regul Integr Comp Physiol 299:R1396–R1406
Miyahara Y, Nagaya N, Kataoka M et al. (2006) Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 12:459–465
Moro C, Crampes F, Sengenès C et al. (2004) Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans. FASEB J 18:908–910
Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480:104–108
Nielsen S, Guo Z, Johnson CM et al. (2004) Splanchnic lipolysis in human obesity. J Clin Invest 113:1582–1588
Ortega FJ, Moreno-Navarrete JM, Pardo G et al. (2010) MiRNA expression profile of human subcutaneous adipose and during adipozyte differentiation. PLoS One 5:e9022
Ouellet V, Labbe SM, Blondin DP, Phoenix S, Guerin B, Haman F, Turcotte EE, Richard D, Carpentier AC (2012) Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 122:545–552
Ozcan U, Cao Q, Yilmaz E et al. (2004). Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457–461
Pai JK, Pischon T, Ma J et al. (2004) Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 351:2599–2610
Pajvani UB, Trujillo ME, Combs TP et al. (2005) Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 11:797–803
Pasarica M, Tchoukalova YD, Heilbronn LK et al. (2009) Differential effect of weight loss on adipozyte size subfractions in patients with type 2 diabetes. Obesity 17:1976–1978
Pedersen BK, Steensberg A, Fischer C et al. (2004) The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proc Nutr Soc 63:263–267
Pelleymounter MA, Cullen MJ, Baker MB et al. (1995) Effects of the obese gene-product on body-weight regulation in ob/ob Mice. Science 269:540–543
Pischon T, Girman CJ, Hotamisligil GS et al. (2004) Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291:1730–1737
Planat-Benard V, Silvestre JS, Cousin B et al. (2004) Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation 109:656–663
Ravussin E, Galgani JE (2011) The implication of brown adipose tissue for humans. Annu Rev Nutr 31:33–47
Razani B, Combs TP, Wang XB et al. (2002) Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyzeridemia with adipozyte abnormalities. J Biol Chem 277:8635–864
Roberts R, Hodson L, Dennis AL et al. (2009) Markers of de novo lipogenesis in adipose tissue: associations with small adipozytes and insulin sensitivity in humans. Diabetologia 52:882–890
Rolfe DF, Brand MD (1997) The physiological significance of mitochondrial proton leak in animal cells and tissues. Biosci Rep 17:9–16
Rosen ED, MacDougald OA (2006) Adipozyte differentiation from the inside out. Nat Rev Mol Cell Biol7:885–896
Rupnick MA, Panigrahy D, Zhang CY et al. (2002) Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U.S.A 99:10730–10735
Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58:1526–1531
Sartipy P, Loskutoff DJ (2003) Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U.S.A 100:7265–7270
Sellayah D, Bharaj P, Sikder D (2011) Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab 14:478–490
Sengenès C, Lolmede K, Zakaroff-Girard A et al. (2005) Preadipozytes in the human subcutaneous adipose tissue display distinct features from the adult mesenchymal and hematopoietic stem cells. J Cell Physiol 114–122
Skurk T, Lee YM, Hauner H (2001) Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipozytes in primary culture. Hypertension 37:1336–1340
Skurk T, van Harmelen V, Blum WF, Hauner H (2005) Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2–dependent pathway. Obes Res 13:969–973
Skurk T, Alberti-Huber C, Herder C, Hauner H: Relationship between adipozyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92:1023–1033
Skurk T, Hauner H (2012) Primary culture of human adipozyte precursor cells: expansion and differentiation. Methods Mol Biol806:215–226
Slavin BG, Ballard KW (1978) Morphological studies on the adrenergic innervation of white adipose tissue. Anat Rec 191:377–389
Smith SA (2003) Central role of the adipozyte in the insulin-sensitising and cardiovascular risk modifying actions of the thiazolidinediones. Biochimie 85:1219–1230
Soderlund V, Larsson SA, Jacobsson H (2007) Reduction of FDG uptake in brown adipose tissue in clinical patients by a single dose of propranolol. Eur J Nucl Med Mol Imaging 34:1018–1022
Spalding KL, Arner E, Westermark PO et al. (2008) Dynamics of fat cell turnover in humans. Nature 453:783–787
Spencer M, Unal R, Zhu B et al. (2011) Adipose tissue extracellular matrix and vascular abnormalities in obesity and insulin resistance. J Clin Endocrinol Metab 96:E1990–1998
Spranger J, Kroke A, Möhlig M et al. (2003) Adiponectin and protection against type 2 diabetes mellitus. Lancet 361:226–228
Spranger J, Verma S, Gohring I et al. (2006) Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes 55:141–147
Stefan N, Hennige AM, Staiger H et al. (2007) High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care 30:1173–1178
Symonds ME, Mostyn A, Pearce S, Budge H, Stephenson T (2003) Endocrine and nutritional regulation of fetal adipose tissue development. J Endocrinol 179:293–299
Trujillo ME, Scherer PE (2006) Adipose tissue-derived factors: impact on health and disease. Endocr Rev 27:762–778
Tseng YH, Cypess AM, Kahn CR (2010) Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 9:465–482
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR (2008) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454:1000–1004
Tso AW, Xu A, Sham PC et al. (2007) Serum adipozyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care 30:2667–2672
Tuncman G, Erbay E, Hom X et al. (2006) A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyzeridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci U.S.A 103:6970–6975
Unger RH (2002) Lipotoxic diseases. Annu Rev Med 53:319–336
Vegiopoulos A, Muller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel DM, Rozman J, Hrabe de AM, Nusing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipozytes. Science 328:1158–1161
Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P (2009) Functional brown adipose tissue in healthy adults. N Engl J Med 360:1518–1525
Virtanen KA, Lönnroth P, Parkkola R et al. (2002) Glukose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J Clin Endocrinol Metab 87:3902–3910
Wallenius V, Wallenius K, Ahren B et al. (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8:75–79
Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J (2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:484–489
Weisberg SP, McCann D, Desai M et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808
Welsh GI, Griffiths MR, Webster KJ et al. (2004) Proteome analysis of adipogenesis. Proteomics 4:1042–1051
Weyer C, Foley JE, Bogardus C et al. (2000) Enlarged subcutaneous abdominal adipozyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 43:1498–1506
Wirth A, Diehm C, Hanel W et al. (1985) Training-induced changes in serum lipids, fat tolerance, and adipose tissue metabolism in patients with hypertriglyzeridemia. Atherosclerosis 54:263–271
Xu A, Tso AW, Cheung BM et al. (2007) Circulating adipozyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation 115:1537–1543
Xu H, Barnes GT, Yang Q et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821–1830
Yang Q, Graham TE, Mody N et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436:356–362
Yoshizaki T, Kusunoki C, Kondo M et al. (2012) Autophagy regulates inflammation in adipozytes. Biochem Biophys Res Commun 417:352–357
Youn BS, Klöting N, Kratzsch J et al. (2008) Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes 57:372–377
Zaragosi LE, Wdziekonski B, Brigand KL et al. (2011) Small RNA sequencing reveals miR-642a-3p as a novel adipozyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol 12:R64
Zechner R, Zimmermann R, Eichmann TO et al. (2012) Fat signals-lipases and lipolysis in lipid metabolism and signaling. Cell Metab 15:279–291
Zhang Y, Proenca R, Maffei M et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432
Zuk PA (2010) The adipose-derived stem cell: looking back and looking ahead. Mol Biol Cell 21:1783–1787
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Engeli, S., Skurk, T., Blüher, M., Klingenspor, M. (2013). Fettgewebe. In: Wirth, A., Hauner, H. (eds) Adipositas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22855-1_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-22855-1_5
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-22854-4
Online ISBN: 978-3-642-22855-1
eBook Packages: Medicine (German Language)