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Semiology and Pattern Analysis in Nonmelanocytic Lesions

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Reflectance Confocal Microscopy for Skin Diseases

Abstract

Confocal microscopy has been used in the study of ­nonmelanocytic tumors since the beginning of the technology [1]. Numerous publications have provided criteria and descriptors for different neoplasms such as basal cell carcinoma, keratinizing tumors, angioma and dermatofibroma among others. The limits of resolution and depth of the microscope make impossible the observation of the tumor component in the reticular dermis and hypodermis and therefore RCM is not useful for the study of the deep component of thick lesions of the skin. Likewise RCM cannot provide reliable information in deep recurrences or surgical margins in the case of carcinoma prior to surgery [2]. Moreover, RCM can be very sensible and specific in the detection of the superficial part of the tumor that is sufficient for a correct diagnosis in many cutaneous neoplasms. In the case of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), different application of RCM in the ex vivo modality with the use of specific staining products for RCM such as acridine has been reported. Ex vivo RCM has been postulated to be useful in MOHS surgery in theses tumors [3].

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Authors and Affiliations

  1. Department of Dermatology, Melanoma Unit, Hospital Clinic of Barcelona, Barcelona, Spain

    Josep Malvehy, Myrna Hanke-Martinez, Joanne Costa, Gabriel Salerni, Cristina Carrera & Susana Puig

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  1. Josep Malvehy
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  2. Myrna Hanke-Martinez
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  3. Joanne Costa
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  4. Gabriel Salerni
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  5. Cristina Carrera
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  6. Susana Puig
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Correspondence to Josep Malvehy .

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Editors and Affiliations

  1. Klinik für Dermatologie und Venerologie, Universitätsklinikum Graz, Auenbruggerplatz 8, Graz, 8036, Austria

    Rainer Hofmann-Wellenhof

  2. Dipto. Dermatología, Università de Modena y Reggio Emilia, Via del Pozzo 71, Modena, 41100, Italy

    Giovanni Pellacani

  3. Barcelona, Melanoma Unit, Hospital Clínic i Provincial de, C/ Villarroel 170, Barcelona, 08036, Spain

    Joseph Malvehy

  4. , Princess Alexandra Hospital, The University of Queensland School of, 199 Ipswich Road, Woolloongabba, Brisbane, 4102, Queensland, Australia

    Hans Peter Soyer

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Malvehy, J., Hanke-Martinez, M., Costa, J., Salerni, G., Carrera, C., Puig, S. (2012). Semiology and Pattern Analysis in Nonmelanocytic Lesions. In: Hofmann-Wellenhof, R., Pellacani, G., Malvehy, J., Soyer, H. (eds) Reflectance Confocal Microscopy for Skin Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21997-9_18

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  • DOI: https://doi.org/10.1007/978-3-642-21997-9_18

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-21996-2

  • Online ISBN: 978-3-642-21997-9

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