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The Role of Ets Transcription Factors in Mediating Cellular Transformation

  • Chapter
Book cover Transcription Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 166))

Abstract

The Ets family of transcription factors in mouse or humans is comprised of around 27 unique family members that contain an evolutionarily conserved DNA-binding domain called the Ets domain. The Ets family includes both transcriptional activators and repressors. The normal cellular Ets transcription factors have been implicated as mediators of a wide range of cellular processes, including oncogenic transformation. This chapter provides an overview of the Ets family, and describes each of the multiple lines of evidence that Ets transcription factors are mediators of cellular transformation. This evidence includes: (a) cancers resulting from Ets factor overexpression or chromosomal translocations that generate fusion proteins containing Ets factor domains; (b) signaling from oncogenes to Ets factors; (c) expression correlation of Ets factors with tumor formation; (d) reversal of cellular transformation by dominant inhibitory Ets constructs; (e) delayed tumor development after genetic disruption of an Ets factor; and (f) the potential role of many Ets target genes in transformation. A better understanding of the role of Ets factors and their target genes in cancer should provide the basis for more specific novel therapeutic approaches for the treatment of cancers.

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  1. La Jolla Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    G. Foos & C. A. Hauser

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  1. G. Foos
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  2. C. A. Hauser
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  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

    Manfred Gossen

  2. atugen AG, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

    Jörg Kaufmann

  3. Department of Biochemistry and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

  4. Graduate Program in Cell and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

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Foos, G., Hauser, C.A. (2004). The Role of Ets Transcription Factors in Mediating Cellular Transformation. In: Gossen, M., Kaufmann, J., Triezenberg, S.J. (eds) Transcription Factors. Handbook of Experimental Pharmacology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18932-6_8

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