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Phosphoinositide 3-kinase in Health and Disease

Volume 2

  • Book
  • © 2011

Overview

Editors:
  1. Christian Rommel

    1. Intellikine, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Bart Vanhaesebroeck

    1. , Institute of Cancer and the London Schoo, Queen Mary, University of London, London, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  3. Peter K. Vogt

    1. , Dept. Molecular & Exp. Medicine, Scripps Research Institute, La Jolla, USA

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  • From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress.

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 347)

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About this book

PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-x
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  2. PI3K: From the Bench to the Clinic and Back

    • Bart Vanhaesebroeck, Peter K. Vogt, Christian Rommel
    Pages 1-19

  3. Oncogenic Mutations of PIK3CA in Human Cancers

    • Yardena Samuels, Todd Waldman
    Pages 21-41

  4. Structural Effects of Oncogenic PI3Kα Mutations

    • Sandra B. Gabelli, Chuan-Hsiang Huang, Diana Mandelker, Oleg Schmidt-Kittler, Bert Vogelstein, L. Mario Amzel
    Pages 43-53

  5. Comparing the Roles of the p110α and p110β Isoforms of PI3K in Signaling and Cancer

    • Nina Ilić, Thomas M. Roberts
    Pages 55-77

  6. Phosphatidylinositol 3-Kinase: The Oncoprotein

    • Peter K. Vogt, Jonathan R. Hart, Marco Gymnopoulos, Hao Jiang, Sohye Kang, Andreas G. Bader et al.
    Pages 79-104

  7. AKT Signaling in Physiology and Disease

    • Krishna M. Vasudevan, Levi A. Garraway
    Pages 105-133

  8. Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse

    • Caterina Nardella, Arkaitz Carracedo, Leonardo Salmena, Pier Paolo Pandolfi
    Pages 135-168

  9. PI3K as a Target for Therapy in Haematological Malignancies

    • Asim Khwaja
    Pages 169-188

  10. Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors

    • Carlos L. Arteaga
    Pages 189-208

  11. From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development

    • Saveur-Michel Maira, Peter Finan, Carlos Garcia-Echeverria
    Pages 209-239

  12. New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling from a New Generation of Tor Kinase Domain Inhibitors (TORKinibs)

    • Morris E. Feldman, Kevan M. Shokat
    Pages 241-262

  13. Small Molecule Inhibitors of the PI3-Kinase Family

    • Zachary A. Knight
    Pages 263-278

  14. Targeting the RTK-PI3K-mTOR Axis in Malignant Glioma: Overcoming Resistance

    • Qi-Wen Fan, William A. Weiss
    Pages 279-296

  15. Back Matter

    Pages 297-304
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Editors and Affiliations

  • Intellikine, La Jolla, USA

    Christian Rommel

  • , Institute of Cancer and the London Schoo, Queen Mary, University of London, London, United Kingdom

    Bart Vanhaesebroeck

  • , Dept. Molecular & Exp. Medicine, Scripps Research Institute, La Jolla, USA

    Peter K. Vogt

Bibliographic Information

  • Book Title: Phosphoinositide 3-kinase in Health and Disease

  • Book Subtitle: Volume 2

  • Editors: Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-14816-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2011

  • Hardcover ISBN: 978-3-642-14815-6Published: 01 October 2010

  • Softcover ISBN: 978-3-642-26530-3Published: 03 December 2012

  • eBook ISBN: 978-3-642-14816-3Published: 17 October 2010

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 306

  • Number of Illustrations: 33 b/w illustrations, 46 illustrations in colour

  • Topics: Cancer Research

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