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Diverse Effects of Hypoxia on Tumor Progression

  • Book
  • © 2010

Overview

Editors:
  1. M. Celeste Simon

    1. Medicine, University of Pennsylvania School of, Philadelphia, USA

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  • Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 345)

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About this book

Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The HIF-2α-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization

    • Alexander Pietras, A. Sofie Johnsson, Sven Påhlman
    Pages 1-20

  3. Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance

    • Zhizhong Li, Jeremy N. Rich
    Pages 21-30

  4. Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression

    • Amato J. Giaccia, Ernestina Schipani
    Pages 31-45

  5. The Role of Hypoxia Regulated microRNAs in Cancer

    • Robert McCormick, Francesca M. Buffa, Jiannis Ragoussis, Adrian L. Harris
    Pages 47-70

  6. Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration

    • Annelies Quaegebeur, Peter Carmeliet
    Pages 71-103

  7. Hypoxia-Inducible Factors as Essential Regulators of Inflammation

    • Hongxia Z. Imtiyaz, M. Celeste Simon
    Pages 105-120

  8. Hypoxia and Metastasis in Breast Cancer

    • Helene Rundqvist, Randall S. Johnson
    Pages 121-139

  9. Back Matter

    Pages 141-143
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Editors and Affiliations

  • Medicine, University of Pennsylvania School of, Philadelphia, USA

    M. Celeste Simon

Bibliographic Information

  • Book Title: Diverse Effects of Hypoxia on Tumor Progression

  • Editors: M. Celeste Simon

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-13329-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2010

  • Hardcover ISBN: 978-3-642-13328-2Published: 05 September 2010

  • Softcover ISBN: 978-3-642-26484-9Published: 05 November 2012

  • eBook ISBN: 978-3-642-13329-9Published: 28 September 2010

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 146

  • Topics: Cancer Research, Embryology, Human Physiology

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