Synonyms
Definition
Nucleic acids are long, unbranched polymers of nucleotides. Each nucleotide monomer consists of a nitrogenous base, a pentose sugar, plus a phosphate group. Nucleotides polymerize by chemically linking a phosphate group at the 5′ position of one nucleotide to the hydroxyl group at the 3′ position of the next nucleotide. The linkage creates a phosphodiester bond, releasing a water molecule. In its two principle forms, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA), nucleic acids store, transcribe, and translate genetic information into the diverse array of proteins needed for execution of almost every cellular process.
Overview
The large, complex molecules of life are carbon-based, and fall into four broad categories: carbohydrates, lipids,...
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References and Further Reading
Crick F (1970) Central dogma of molecular biology. Nature 226:561–563
Devoe H, Tinoco I Jr (1962) The stability of helical polynucleotides: base contributions. J Mol Biol 4:500–517
Franklin RE, Gosling RG (1953) The structure of sodium thymonucleate fibres. I. The influence of water content. Acta Crystallogr 6(8–9):673–677
Gilbert W (1986) Origin of life: the RNA world. Nature 319(6055):618–618
Guerrier-Takada C, Gardiner K, Marsh T, Pace N, Altman S (1983) The RNA moiety of ribonuclease P Is the catalytic subunit of the enzyme. Cell 35(3 Pt 2):849–857
Hsiao C, Mohan S, Kalahar BK, Williams LD (2009) Peeling the onion: ribosomes are ancient molecular fossils. Mol Biol Evol 26(11):2415–2425
Kim SH, Sussman JL, Suddath FL, Quigley GJ, McPherson A, Wang AH, Seeman NC, Rich A (1974) The general structure of transfer RNA molecules. Proc Natl Acad Sci U S A 71(12):4970–4974
Kornberg RD (2007) The molecular basis of eukaryotic transcription. Proc Natl Acad Sci U S A 104(32):12955–12961
Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR (1982) Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena. Cell 31(1):147–157
Lescoute A, Leontis NB, Massire C, Westhof E (2005) Recurrent structural RNA motifs, Isostericity matrices and sequence alignments. Nucleic Acids Res 33(8):2395–2409
Mullis KB, Faloona FA (1987) Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Meth Enzymol 155:335–350
Oro J, Kimball AP (1962) Synthesis of purines under possible primitive earth conditions. II. Purine intermediates from hydrogen cyanide. Arch Biochem Biophys 96:293–313
Poole AM, Jeffares DC, Penny D (1998) The path from the RNA world. J Mol Evol 46(1):1–17
Rich A (1962) In: Kasha M, Pullman B (eds) Horizons in biochemistry. Academic, New York, pp 103–126
Roberts RJ (1976) Restriction endonucleases. CRC Crit Rev Biochem 4(2):123–164
Saenger W (1984) Principles of nucleic acid structure. Springer, New York, p 556
Schmitt-Kopplin P, Gabelica Z, Gougeon RD, Fekete A, Kanawati B, Harir M, Gebefuegi I, Eckel G, Hertkorn N (2010) High molecular diversity of extraterrestrial organic matter in murchison meteorite revealed 40 years after its fall. Proc Natl Acad Sci U S A 107(7):2763–2768
Voet JG, Voet D (2003) Biochemistry. Wiley, New York
Watson JD, Crick FH (1953) Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid. Nature 171(5451):737–738
Woese CR, Fox GE (1977) Phylogenetic structure of the prokaryotic domain: the primary kingdoms. Proc Natl Acad Sci U S A 74(11):5088–5090
Zamenhof S, Brawerman G, Chargaff E (1952) On the desoxypentose nucleic acids from several microorganisms. Biochim Biophys Acta 9(4):402–405
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Bowman, J.C., Williams, L.D. (2011). Nucleic Acids. In: Gargaud, M., et al. Encyclopedia of Astrobiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11274-4_1079
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