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IGFs:Local Repair and Survival Factors Throughout Life Span pp 143–153Cite as

The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span

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Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

Abstract

There is growing evidence to suggest a role for GH/IGF system in regulation of life span, or rate of aging. The role of IGF-1 in aging and disease is very complex. High IGF-1 levels is associated with cancers and low IGF-1 has been implicated in the pathogenesis of a wide range of conditions including diabetes and glucose intolerance, osteoporosis, poor cognitive function and coronary heart disease, thus highlighting the complex role of IGF axis in humans. In addition, we have shown that members of GH/IGF axis, IGF-1, IGFBP-3 as well as a novel binding partner for IGFBP-3 termed HN influence glucose metabolism through the hypothalamus. This suggests that acute regulation of peripheral insulin action is probably elicited in the hypothalamus and the integrity of GH/IGF system is probably needed to ensure normal metabolism with aging. Therefore, it is intriguing to speculate that an ability to ameliorate the age-associated decline in CSF IGF-1 levels without increasing circulating IGF-1 levels would be beneficial in potentially preventing or treating two scourges with enormous morbidity and mortality, diabetes and cancer. Potentially, administration of IGF-1 receptor antagonists that does not cross the blood brain barrier, will protect peripheral tissues from cancer, yet will allow IGF-1 to act in the brain to allow the beneficial effects related to other diseases such as cognition and glucose tolerance. In addition, the newest link to IGF system, HN could offer exciting patho-physiologic links as well as potential treatment options for neuro-degeneration and diabetes.

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Acknowledgments

This work was supported by grants from the National Institutes of Health (K08 AG027462 to R.H.M and AG21654 and AG18381 to N.B.) and by the Core laboratories of the Albert Einstein Diabetes Research and Training Center (DK 20541).

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Authors and Affiliations

  1. Institute for Aging Research, Departments of Medicine and Molecular Genetics, The Albert Einstein College of Medicine, Belfer Building, Suite 701, Bronx, USA

    Nir Barzilai

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  1. Nir Barzilai
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  2. Derek M. Huffman
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  3. Pinchas Cohen
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  4. Radhika H. Muzumdar
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Correspondence to Nir Barzilai .

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Editors and Affiliations

  1. Chapel Hill, University of North Carolina, Burnett-Womack Hall 8024, Chapel Hill, 27599-7170, U.S.A.

    David Clemmons

  2. Lab. Endocrine Physiology, National Inst. Med. Research, The Ridgeway, London, NW7 1AA, United Kingdom

    Iain C.A.F. Robinson

  3. Recherche Therapeutique, Fondation IPSEN pour la, quai George Gorse 65, Boulogne Billancourt Cedex, 92650, France

    Yves Christen

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Barzilai, N., Huffman, D.M., Cohen, P., Muzumdar, R.H. (2010). The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span. In: Clemmons, D., Robinson, I., Christen, Y. (eds) IGFs:Local Repair and Survival Factors Throughout Life Span. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04302-4_11

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  • DOI: https://doi.org/10.1007/978-3-642-04302-4_11

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