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Bioreactor and scaffold design for the mechanical stimulation of silk based anterior cruciate ligament grafts

  • Conference paper
World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany

Part of the book series: IFMBE Proceedings ((IFMBE,volume 25/10))

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Abstract

A bioreactor for the mechanical stimulation of silk based scaffolds has been developed. The bioreactor simulates the natural movement of the anterior cruciate ligament by applying a biaxial movement on the scaffold. The silk scaffolds are prepared in a way that mimicks the mechanical properties (strength, stiffness) of natural anterior cruciate ligaments. The influence of degumming on the mechanical properties of the scaffolds is investigated and first results on cell cultivation experiments with fibroblasts are presented.

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Author information

Authors and Affiliations

  1. A.M.I. Agency for Medical Innovations, Feldkirch, Austria

    M. Hohlrieder

  2. Inst. of Materials Science and Technology, TU Wien, Vienna, Austria

    K. Cicha & J. Stampfl

  3. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria

    A. Teuschl, M. van Griensven & H. Redl

Authors
  1. M. Hohlrieder
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  2. K. Cicha
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  3. A. Teuschl
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  4. M. van Griensven
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  5. H. Redl
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  6. J. Stampfl
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Editor information

Editors and Affiliations

  1. Inst. Biomedizinische Technik, Univ. Karlsruhe, Kaiserstr. 12, 76128, Karlsruhe, Germany

    Olaf Dössel

  2. Abt. Medizinische Physik in der Strahlentherapie, Deutsche Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Wolfgang C. Schlegel

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© 2009 Springer-Verlag Berlin Heidelberg

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Hohlrieder, M., Cicha, K., Teuschl, A., van Griensven, M., Redl, H., Stampfl, J. (2009). Bioreactor and scaffold design for the mechanical stimulation of silk based anterior cruciate ligament grafts. In: Dössel, O., Schlegel, W.C. (eds) World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, vol 25/10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03900-3_60

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  • DOI: https://doi.org/10.1007/978-3-642-03900-3_60

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03899-0

  • Online ISBN: 978-3-642-03900-3

  • eBook Packages: EngineeringEngineering (R0)

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