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Inflammation and Gastrointestinal Cancers

  • Book
  • © 2011

Overview

Editors:
  1. Janusz A. Z. Jankowski

    1. Leicester Royal Infirmary, Dept. Cancer Studies and, University of Leicester, Leicester, United Kingdom

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  • Discusses all aspects of the relation between inflammation and GI cancer, from the basic science through to the translational science which is helping in the optimization of clinical management strategies
  • Written by experts in the field
  • Designed for the enthusiastic student as well as the professional in GI science and medicine

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 185)

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About this book

Inflammation in gastrointestinal mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it has fundamental clinical consequences, the principal of which is premalignant metaplasia throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for GI cancer.

This book discusses all aspects of the relation between inflammation and GI cancer, from the basic science through to the translational science which is helping in the optimization of clinical management strategies. Among the topics considered are the impact of inherited syndromes; the roles of acid reflux, H. pylori, inflammatory bowel disease, and primary sclerosing cholangitis; screening strategies; targeted drug therapies; genetics; and the use of endoscopic methods. The authors are the best in their field, and this book is designed for the enthusiastic student as well as the professional in GI science and medicine.

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-ix
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  2. Basic Concepts of Inflammation and its Role in Carcinogenesis

    • Stephen G. Maher, John V. Reynolds
    Pages 1-34

  3. Inherited Syndromes Predisposing to Inflammation and GI Cancer

    • Shane Duggan, David Prichard, Murat Kirca, Dermot Kelleher
    Pages 35-50

  4. Stem Cells and Inflammation in the Intestine

    • Adam Humphries, Trevor A. Graham, Stuart A. C. McDonald
    Pages 51-63

  5. Acid Reflux and Oesophageal Cancer

    • Anna Nicholson, Janusz Jankowski
    Pages 65-82

  6. Helicobacter pylori and Gastric Cancer

    • Michael Rathbone, Barrie Rathbone
    Pages 83-97

  7. Inflammatory Bowel Disease and Colon Cancer

    • Noor Jawad, Natalie Direkze, Simon J. Leedham
    Pages 99-115

  8. Primary Sclerosing Cholangitis

    • Piotr Milkiewicz, Ewa Wunsch
    Pages 117-133

  9. Chronic Inflammation and Hepatocellular Carcinoma

    • Malcolm R. Alison, Linda J. Nicholson, Wey-Ran Lin
    Pages 135-148

  10. Gastrointestinal Cancer: Current Screening Strategies

    • Hugh Barr
    Pages 149-157

  11. Targeted Drug Therapies and Cancer

    • K. L. Yim, D. Cunningham
    Pages 159-171

  12. Genetics of Inflammation in the Gastrointestinal Tract and How it Can Cause Cancer

    • Mairi H. McLean, Emad M. El-Omar
    Pages 173-183

  13. Endoscopic Methods

    • Gaius Longcroft-Wheaton, Pradeep Bhandari
    Pages 185-199
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Editors and Affiliations

  • Leicester Royal Infirmary, Dept. Cancer Studies and, University of Leicester, Leicester, United Kingdom

    Janusz A. Z. Jankowski

Bibliographic Information

  • Book Title: Inflammation and Gastrointestinal Cancers

  • Editors: Janusz A. Z. Jankowski

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-03503-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2011

  • Hardcover ISBN: 978-3-642-03502-9Published: 08 August 2011

  • Softcover ISBN: 978-3-642-26838-0Published: 15 July 2013

  • eBook ISBN: 978-3-642-03503-6Published: 08 August 2011

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: X, 202

  • Topics: Oncology, Gastroenterology

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