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Small Molecules in Oncology

  • Book
  • © 2010

Overview

Editors:
  1. Uwe M. Martens

    1. Medizinische Klinik III, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany

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  • Provides a broad overview of the small molecules currently used for the treatment of malignant diseases
  • Discusses interesting novel compounds that are in the process of clinical development to combat cancer
  • Written by acknowledged experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 184)

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About this book

Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Protein kinase inhibitors

    1. Front Matter

      Pages 1-1
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    2. Imatinib Mesylate

      • Cornelius F. Waller
      Pages 3-20

    3. Erlotinib

      • M. Steins, M. Thomas, M. Geißler
      Pages 21-31

    4. Axitinib (AG-013736)

      • Ronan Joseph Kelly, Olivier Rixe
      Pages 33-44

    5. Lapatinib

      • Tanja Schneider-Merck, Martin Trepel
      Pages 45-59

    6. Sorafenib

      • Jens Hasskarl
      Pages 61-70

    7. Sunitinib

      • Daniel Y. C. Heng, Christian Kollmannsberger
      Pages 71-82

    8. Dasatinib

      • Markus Lindauer, Andreas Hochhaus
      Pages 83-102

    9. Nilotinib

      • Alfonso Quintás-Cardama, Theo Daniel Kim, Vince Cataldo, Philipp le Coutre
      Pages 103-117

    10. Bosutinib

      • Gunhild Keller, Philippe Schafhausen, Tim H. Brümmendorf
      Pages 119-127

  3. Epigenetic modifiers

    1. Front Matter

      Pages 130-130
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    2. Decitabine

      • Michael Daskalakis, Nadja Blagitko-Dorfs, Björn Hackanson
      Pages 131-157

    3. 5-Azacytidine/Azacitidine

      • Antonia Müller, Mareike Florek
      Pages 159-170

  4. Cell cycle inhibitors

    1. Front Matter

      Pages 172-172
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    2. Bortezomib

      • Hermann Einsele
      Pages 173-187

    3. Temsirolimus

      • Christian Stock, Massimo Zaccagnini, Michael Schulze, Dogu Teber, Jens J. Rassweiler
      Pages 189-197

    4. Danusertib (formerly PHA-739358) – A Novel Combined Pan-Aurora Kinases and Third Generation Bcr-Abl Tyrosine Kinase Inhibitor

      • Artur Gontarewicz, Tim H. Brümmendorf
      Pages 199-214

    5. BI_2536 - Targeting the Mitotic Kinase Polo-Like Kinase 1 (Plk1)

      • R. Wäsch, J. Hasskarl, D. Schnerch, M. Lübbert
      Pages 215-218

  5. Other novel agents

    1. Front Matter

      Pages 220-220
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Editors and Affiliations

  • Medizinische Klinik III, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany

    Uwe M. Martens

Bibliographic Information

  • Book Title: Small Molecules in Oncology

  • Editors: Uwe M. Martens

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-01222-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2010

  • Softcover ISBN: 978-3-642-26145-9Published: 04 May 2012

  • eBook ISBN: 978-3-642-01222-8Published: 14 January 2010

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XVI, 238

  • Topics: Oncology, Hematology, Cancer Research

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