This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Krutmann J, Morita A (2003) Therapeutic photomedicine phototherapy. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI (eds) Fitzpatrick's dermatology in general medicine. McGraw Hill, New York
Krutmann J, Morita A, Elmets CA (2001) Mechanism of photo(chemo)therapy. In: Krutmann J, Hönigsmann H, Elmets CA, Bergstresser PR (eds) Dermatological phototherapy and photodiagnostic methods. Springer, New York, p 54
Parrish JA, Jaenicke KF (1980) Action spectrum for phototherapy of psoriasis. J Invest Dermatol 76:359–362
Walters IB, Burack LH, Coven TR et al (1999) Suberythe-mogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris. J Am Acad Dermatol 40:893–900
Ozawa M, Ferenczi K, Kikuchi T et al (1999) 312-nanome-ter ultraviolet B light (narrow-band UVB) induces apopto-sis of T cells within psoriatic lesions. J Exp Med 189:711–718
Shintani Y, Morita A (2008). Narrowband UVB radiation suppresses contact hypersensitivity. Photodermatol Photo-immunol Photomed 24:32–37
Sakaguchi S (2004) Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22:531–562
Shevach EM (2002) CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2:389–400
Loser K, Mehling A, Loeser S et al (2006) Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med 12:1372–1379
Schwarz A, Maeda A, Kernebeck K, van Steeg H, Beissert S, Schwarz T (2005) Preventionof UV radiation-induced immunosuppression by IL-12 is dependent on DNArepair. J Exp Med 201:173–179
Moodycliffe AM, Kimber I, Norval M (1992) The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration. Immunology 77:394–399
Mizuno K, Okamoto H, Horio T (2004) Ultraviolet B radiation suppresses endocytosis, subsequent maturation, and migration activity of Langerhans cell-like dendritic cells. J Invest Dermatol 122:300–306
Yamazaki S, lyoda T, Tarbell K et al (2003) Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 198:235–247
Ghoreishi M, Dutz JP (2006) Tolerance induction by trans-cutaneous immunization through ultraviolet-irradiated skin is transferable through CD4 + CD25+ T regulatory cells and is dependent on host-derived IL-10. J Immunol 176:2635–2644
Novak Z, Berces A, Konto G et al (2004) Efficacy of differ-enl UV-emitting light sources in the induction of T-cell apoptosis. Photochem Photobiol 79:434–439
George SA, Bilsland DJ, Johnson BE, Ferguson J (1993) Narrow-band (TL-01) UVB air conditioned phototherapy for chronic severe adult atopic dermatitis. Br J Dermatol 128:49–56
Reynolds NJ, Franklin V, Gray JC, Diffey BL, Farr PM (2001) Narrow-band ultraviolet B and broad-band ultraviolet A phototherapy in adult atopic eczema: a randomised controlled trial. Lancet 357:2012–2016
Bonis B, Kemeny L, Dobozu A et al (1997) 308 nm UVB excimer laser for psoriasis. Lancet 350:1522
Aubin F, Vigin M, Puzenat E et al (2005) Evaluation of a novel monochromaticexcimer light delivery system in dermatology: a pilot study in different chronic localized dermatoses. Br J Dermatol 152:99–103
Man I, Crombie IK, Dawe RS et al (2005) The photocarcino-genic risk of narrowband UVB(TL-Ol) phototherapy: early follow-up data. Br J Dermatol 152:755–757
Morita A, Werfel T, Stege H et al (1997) Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J Exp Med 186:1763–1768
Krutmann J, Czech W, Dicpgen T et al (1992) High-dose UVA1 therapy in the treatment of patients with atopic dermatitis. J Am Acad Dermatol 26:225–230
Krutmann J, Morita A (2005) Phototherapy for atopic dermatitis. In: Ring J, Ruzicka T, Przybilla B (eds) Handbook of atopic eczema, 2nd edn. Springer, Heidelberg, pp 539–542
Yin L, Morita A, Tsuji T (2003) The crucial role of TGF-beta in the age-related alterations induced by ultraviolet A Irradiation. J Invest Dermatol 120:703–705
Herrmann G, Wlaschek M, Lange TS et al (1993) UVA Irradiation stimulates the synthesis of various matrix metal-loproteinases (MMPs). Exp Dermatol 2:92–97
Yin L, Yamauchi R, Tsuji T, Krutmann J, Morita A (2003) The expression of matrixmetalloproteinase-1 mRNA induced by ultraviolet AI (340–400nm) is phototherapy relevant to the glutathione (GAH) content in skin fibroblasts of systemic sclerosis. J Dermatol 30:173–180
Sakakibara N, Morita A (2008) Ultrastructural changes induced in cutaneous collagen by UVA l and PUVA therapy in systemic sclerosis. J Dermatol 35:63–69
Chizzolini C, Rezzonico R, Ribbens C et al (1998) Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: different sensitivity to inhibition between systemic sclerosis and control fibroblast. Arthritis Rheum 41:2039–2047
Scharffetter K, Wlaschek M, Hogg A et al (1999) U VA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch Dermatol Res 283:506–511
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Morita, A. (2010). Ultraviolet (UV) A and (UV) B Phototherapy. In: Krieg, T., Bickers, D.R., Miyachi, Y. (eds) Therapy of Skin Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78814-0_9
Download citation
DOI: https://doi.org/10.1007/978-3-540-78814-0_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-78813-3
Online ISBN: 978-3-540-78814-0
eBook Packages: MedicineMedicine (R0)