Viruses and Apoptosis

1. Front Matter

   Pages I-XVI

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2. Cell Death Suppressors Encoded by Cytomegalovirus

   • V. S. Goldmacher

   Pages 1-18

3. Apoptosis Regulator Genes Encoded by Poxviruses

   • M. Barry, S. T. Wasilenko, T. L. Stewart, J. M. Taylor

   Pages 19-37

4. T-Cell-Mediated Control of Poxvirus Infection in Mice

   • A. Müllbacher, R. V. Blanden

   Pages 39-55

5. Switching on and Off the Cell Death Cascade: African Swine Fever Virus Apoptosis Regulation

   • B. Hernáez, J. M. Escribano, C. Alonso

   Pages 57-69

6. Neuronal Apoptosis Pathways in Sindbis Virus Encephalitis

   • Pablo M. Irusta, J. Marie Hardwick

   Pages 71-93

7. Apoptotic Pathways Triggered By HIV and Consequences on T Cell Homeostasis and HIV-Specific Immunity

   • M.-L. Gougeon

   Pages 95-115

8. HIV and Apoptosis: a Complex Interaction Between Cell Death and Virus Survival

   • M. Bermejo, J. Alcamí, J. Gil

   Pages 117-149

9. Poliovirus and Apoptosis

   • B. Blondel, T. Couderc, Y. Simonin, A.-S. Gosselin, F. Guivel-Benhassine

   Pages 151-169

10. Flaviviruses and Apoptosis Regulation

    • A. Cetteau, M.-P. Courageot, P. Desprès

    Pages 171-189

11. Manipulation of Apoptosis by Herpes Viruses (Kaposi’s Sarcoma Pathogenesis)

    • P. Feng, C. Scott, S.-H. Lee, N.-H. Cho, J. U. Jung

    Pages 191-205

12. Exploitation of Cell Cycle and Cell Death Controls by Adenoviruses: The Road to a Productive Infection

    • I. Alasdair Russell, J. A. Royds, A. W. Braithwaite

    Pages 207-243

13. Induction of Transformed Cell-Specific Apoptosis by the Adenovirus E4orf4 Protein

    • T. Kleinberger

    Pages 245-267

14. Epstein-Barr Virus Signal Transduction and B-Lymphocyte Growth Transformation

    • K. M. Izumi

    Pages 269-288

15. SV40 and Notch-I: Multi-functionality Meets Pleiotropy

    • M. Carbone, M. Bocchetta

    Pages 289-305

16. Signal Transduction and Apoptosis Pathways as Therapeutic Targets

    • P. F. Valerón, S. Aznar-Benitah, J. C. Lacal

    Pages 307-323

17. Back Matter

    Pages 325-342

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The pathogenesis of viral infections involves dynamic interactions between viruses and hosts,which can result in different outcomes including cell death, elimination of the virus or latent infection.Viruses deliver genomes and p- teins with signaling potential into target cells, resulting in growth, prolife- tion and apoptosis.Viral infection modi?es key cell regulatory elements involved in apoptotic pathways to successfully accomplish viral replication despite the toxicity of viral products and the immune response elicited against the virus.Also,the interplay between virus-induced apoptosis and cell survival is mediated by an accurate balance between pro-death and anti-apoptotic signals triggered by cellular and viral proteins.Hence,viral survival products causing a delay in the completion of apoptotic process can be critical in the replication and propagation of viruses. Viral control of apoptosis can be a double-edged sword.In some viral inf- tions, immune cell apoptosis will contribute to pathogenesis and determine disease evolution either by direct infection of immune cells or as a result of bystander cell apoptosis caused by viral proteins or mediators secreted from infected cells. The apoptotic mechanisms contributing to HIV pathogenesis, the functional consequences on the immune system and the effect of antiviral therapies on this process will be reviewed in depth in this Volume.

• HIV
• Herpes Virus
• Viruses
• apoptosis
• cell
• cell cycle
• cell death
• immunity
• oncogene
• oncogenes
• pathogenesis
• protein
• regulation
• virology
• virus

• Dpt. Biotechnologia, INIA, Madrid, Spain

  Covadonga Alonso

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