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Working Together: the RNA Editing Machinery in Trypanosoma brucei

  • Chapter
RNA Editing

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 20))

Abstract

The proteins in the ∼20S editosome function in a coordinated fashion to catalyze the precise insertion and deletion of uridine nucleotides (Us) in mitochondrial pre-mRNAs, thereby generating functional mRNAs. Many catalytic components of the editosome have been identified, but the abundance of apparently non-catalytic components is a conspicuous reminder that the editosome is much more than the sum of its catalytic activities. As the functions of the various editosome proteins are elucidated, the importance of how they interact in vivo is becoming more evident. Indeed, ∼20S editosomes are compositionally heterogeneous in vivo, and higher-order interactions with proteins of other complexes affect editing. Here, we review the general process of editing, and discuss how the known editosome proteins interact and function to produce translatable mRNAs in vivo.

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Authors and Affiliations

  1. Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA, 98109, USA

    Jason Carnes & Kenneth Stuart

  2. Department of Pathobiology, University of Washington, Seattle, WA, 98195, USA

    Jason Carnes & Kenneth Stuart

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  1. Jason Carnes
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  2. Kenneth Stuart
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  1. Institute of Microbiology and Genetics, Technical University Darmstadt, Schnittspahnstr. 10, 64287, Darmstadt, Germany

    H. Ulrich Göringer

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Carnes, J., Stuart, K. (2008). Working Together: the RNA Editing Machinery in Trypanosoma brucei . In: Göringer, H.U. (eds) RNA Editing. Nucleic Acids and Molecular Biology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73787-2_7

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