Anti-Arthrotic Activity
General Considerations
Multifactorial causes can lead to osteoarthritis (OA), and its pathogenesis is not clearly understood as yet. The main characteristics of OA are the slowly progressing deterioration of the articular cartilage, accompanied by intermitted painful inflammatory episodes, and a continuous subchondral bone remodeling, often resulting in osteophyte formation in non-weight-bearing joint areas. Because of the lack of innervation and vascularization of cartilage, the destruction of this specific tissue remains unnoticed until other joint compartments are involved such as synovial membranes, answering with reactive synovitis to cartilage debris, or mechanoreception changes in the underlying bone, or until the diminution of articular cartilage results in a radiographically detectable joint space narrowing.
Therefore, analgesic and anti-inflammatory therapy has been the major treatment for OA in the past, and NSAIDs still constitute 92%...
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Vogel, H. (2007). Antiarthrotic and Immunomodulatory Activity. In: Vogel, H.G. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70995-4_10
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