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Pharmacology of Platelet Adhesion and Aggregation

  • Chapter
Cell Adhesion

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 165))

Abstract

At the injured vessel wall, blood platelets become activated and adhere to the subendothelial surface as well as to each other. These cellular adhesion processes are required for primary hemostasis, but can also lead to thrombosis. Considerable progress has been made during recent years in understanding the molecular mechanisms underlying platelet activation and adhesion. This knowledge will drive future efforts towards the development of new antiplatelet drugs for the prevention and treatment of cardiovascular diseases.

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Authors and Affiliations

  1. Rudolf Virchow Center for Experimental Biomedicine, Vascular Biology, University of Würzburg, 97078, Würzburg, Germany

    B. Nieswandt

  2. Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    S. Offermanns

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  1. B. Nieswandt
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  2. S. Offermanns
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Correspondence to S. Offermanns .

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  1. Nikolaus-Fiebiger-Zentrum für Molekulare Medizin, Universität Erlangen-Nürnberg, Glückstrasse 6, 91054, Erlangen, Germany

    Jürgen Behrens

  2. Department of Molecular & Cellular Physiology Beckman Center B121, Stanford University School of Medicine, Stanford, CA, 94305-5345, USA

    W. James Nelson Ph.D.

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Nieswandt, B., Offermanns, S. (2004). Pharmacology of Platelet Adhesion and Aggregation. In: Behrens, J., Nelson, W.J. (eds) Cell Adhesion. Handbook of Experimental Pharmacology, vol 165. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68170-0_14

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  • DOI: https://doi.org/10.1007/978-3-540-68170-0_14

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